Antifungal agents and uses thereof
Antimicrobial agents, compositions that include the agent(s) and use(s) thereof are provided. Also disclosed are screening assays for identifying antimicrobial agents.
1. A method of treating a microbial infection comprising administering to a subject in need thereof a composition comprising a compound, or a salt thereof, wherein the compound comprises a structure selected from the following:
wherein, optionally, said composition comprises a pharmaceutically acceptable carrier.
2. The method of claim 1 , wherein said microbial infection is a fungal, bacterial, yeast, or mold infection.
3. The method of claim 2 , wherein said fungal infection is caused by a Candida spp.
4. The method of claim 1 , wherein said subject is a human.
5. A composition comprising an anti-microbial compound, or a salt thereof, said compound comprising: a structure selected from the group consisting of:
6. An article comprising the composition of claim 5 incorporated therein or coated thereto, wherein said article:
a) is a medical device, a cuff, a dressing material, a mesh, a hernia patch, a wound dressing, a bandage, a syringe, gloves, or a household product, a cosmetic product, a pharmaceutical product, a washing or cleaning formulation, a medical device surface, a medical device material, a fabric, a plastic, a surface of a plastic article, a paper, a nonwoven material, a wood, leather, or a metal surface; or
b) comprises a thermoset, thermoplastic, elastomeric, or crosslinked polymer.
7. The article of claim 6 , wherein said medical device is a cardiac-assist device, an artificial heart valve, a catheter, a central line, an intravenous (IV) line, a joint, a stent, a prosthetic implant, a pacemaker, a conduit, a cannula, an appliance, a scaffold, an artificial sphincter, a pessary, a tube, a drain, a trochar or plug, an implant, a rod, a screw, an orthopedic or implantable prosthetic device or appliance, a suture, a drug delivery device, an oral implant, a denture, or a brace.
8. The composition of claim 5 , wherein said anti-microbial compound reduces or inhibits at least one function of a microbial agent.
9. The composition of claim 8 , wherein said at least one function is adhesion, yeast-to-hyphal morphological transition, biofilm formation, or growth.
10. The composition of claim 8 , wherein said microbial agent is a fungus, bacteria, yeast, or mold.
11. The article of claim 6 , wherein said polymer is selected from a polyolefin, polyamide, polyurethane, polyacrylate, polyacrylamide, polycarbonate, polystyrene, polyvinyl acetates, polyvinyl alcohol, polyester, halogenated vinyl polymer, a natural or synthetic rubber, an alkyd resin, an epoxy resin, an unsaturated polyester, an unsaturated polyamide, a polyimide, a silicone, a carbamate containing polymer, a fluorinated polymer, a crosslinkable acrylic resin, an epoxy acrylate, a urethane acrylate, or a polyester acrylate, or a block co-polymer thereof.
12. A method for achieving an antimicrobial, preservative, and/or microorganism adhesion inhibiting effect for the protection within an article and/or material or on the surface of an article and/or material, which method comprises applying the composition of claim 5 or an adduct or salt thereof to said article and/or material.
13. The method of claim 12 , wherein said article and/or material:
a) is a medical device, a cuff, a dressing material, a mesh, a hernia patch, a wound dressing, a bandage, a syringe, gloves, a household product, a cosmetic product, a pharmaceutical product, a washing or cleaning formulation, a medical device surface, a medical device material, a fabric, a plastic, a surface of a plastic article, a paper, a nonwoven material, a wood, leather, or a metal surface; or
b) comprises a thermoset, thermoplastic, elastomeric, or crosslinked polymer.
14. The method of claim 13 , wherein said medical device is a cardiac-assist device, an artificial heart valve, a catheter, a central line, an intravenous (IV) line, a joint, a stent, a prosthetic implant, a pacemaker, a conduit, a cannula, an appliance, a scaffold, an artificial sphincter, a pessary, a tube, a drain, a trochar or plug, an implant, a rod, a screw, an orthopedic or implantable prosthetic device or appliance, a suture, a drug delivery device, an oral implant, a denture, or a brace.
15. The method of claim 12 , wherein said compound reduces or inhibits at least one function of a microbial agent.
16. The method of claim 15 , wherein said at least one function is adhesion, yeast-to-hyphal morphological transition, biofilm formation, or growth.
17. The method of claim 15 , wherein said composition inhibits or reduces adhesion or biofilm formation by a fungus, wherein said fungus is a Candida spp.
18. The method of claim 13 , wherein said polymer is selected from a polyolefin, polyamide, polyurethane, polyacrylate, polyacrylamide, polycarbonate, polystyrene, polyvinyl acetates, polyvinyl alcohol, polyester, halogenated vinyl polymer, a natural or synthetic rubber, an alkyd resin, an epoxy resin, an unsaturated polyester, an unsaturated polyamide, a polyimide, a silicone, a carbamate containing polymer, a fluorinated polymer, a crosslinkable acrylic resin, an epoxy acrylate, a urethane acrylate, or a polyester acrylate, or a block co-polymer thereof.
19. The composition of claim 5 , wherein said compound is
20. The article of claim 11 , wherein said crosslinkable acrylic resin is a substituted acrylic ester.
21. The article of claim 11 , wherein said halogenated vinyl polymer is polyvinyl chloride (PVC).
22. The method of claim 18 , wherein said crosslinkable acrylic resin is a substituted acrylic ester.
23. The method of claim 18 , wherein said halogenated vinyl polymer is polyvinyl chloride (PVC).
24. The method of claim 1 , wherein the composition comprises the following compound: