Cephalosporin compound
View Patent ↗The cephalosporin compound of formula (I) is disclosed, which exhibits antibiotic activity against Gram-negative (e.g., Pseudomonas aeruginosa ) and Gram-positive (e.g., methicillin-resistant Staphylococcus aureus ) bacteria. Methods of manufacturing the compound of formula (I), and uses of the compound in the preparation of pharmaceutical compositions and antibacterial applications are also disclosed.
1. The compound of formula (I), or a pharmacologically acceptable salt thereof:
2. A pharmaceutical composition comprising a therapeutically effective amount of the compound of claim 1 , or a pharmacologically acceptable salt thereof.
3. A method of treating a bacterial infection in a host comprising administering to an infected host a pharmaceutical composition comprising an antibacterially effective amount of a compound of claim 1 or a composition of claim 2 .
4. The method of claim 3 , wherein the bacterial infection is caused by a Gram-negative and/or a Gram-positive bacteria.
5. The method of claim 4 , wherein the Gram-negative bacteria is Pseudomonas aeruginosa and the Gram-positive bacteria is Staphylococcus aureus.
6. A method of treating a methicillin-resistant Staphylococcal infection, comprising parenterally administering to a patient in need thereof a pharmaceutical composition comprising a carrier and a therapeutically effective amount of a compound of claim 1 , or a pharmacologically acceptable salt thereof.
7. The method of claim 6 , wherein the therapeutically effective amount is effective against both a Pseudomonas aeruginosa bacteria and a MRSA bacteria with a MIC of not more than about 2 micrograms/mL.