Ion generation using wetted porous material
The invention generally relates to systems and methods for mass spectrometry analysis of samples. In certain embodiments, the invention provides a mass spectrometry probe including at least one porous material connected to a high voltage source, in which the porous material is discrete from a flow of solvent.
1. A system for analyzing a sample, the system comprising:
a probe holder;
a voltage source;
a probe comprising at least one porous material that tapers to at least one tip, wherein the porous material is discrete from a flow of solvent, wherein the probe is connected to the high voltage source such that an electric field is generated at a tip of the material, wherein the probe is held by the probe holder, and wherein the probe operates without pneumatic assistance; and
a mass analyzer.
2. The system according to claim 1 , wherein the connection of the voltage source to the probe is via the holder.
3. The system according to claim 1 , wherein the porous material is paper.
4. The system according to claim 1 , wherein the porous material is PVDF membrane.
5. The system according to claim 1 , wherein the porous material is a gel.
6. The method according to claim 1 , wherein the porous material is plant tissue.
7. The system according to claim 1 , further comprising a solvent applied to the porous material.
8. The system according to claim 1 , wherein the mass analyzer is for a mass spectrometer or a handheld mass spectrometer.
9. The system according to claim 1 , wherein the mass analyzer is selected from the group consisting of: a quadrupole ion trap, a rectalinear ion trap, a cylindrical ion trap, a ion cyclotron resonance trap system, an orbitrap, a time of flight system, and Fourier Transform ion cyclotron resonance system.
10. The system according to claim 1 , wherein the porous material comprises an internal standard.