IP Library › Granted Patent US 10,016,413
Granted Patent B2
US 10,016,413 · App. 14/025,434 · Granted Jul 10, 2018

Combination dopamine antagonist and opiate receptor antagonist treatment of addictive behavior

Inventors: Jia Bei Wang (Ellicott City, MD); Sarah Sushchyk (Baltimore, MD)
Assignee: University of Maryland, Baltimore
A61K31/485A61K31/473A61K31/4745A61K45/06
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Quick Facts
Patent No.
US 10,016,413
App. No.
14/025,434
Granted
Jul 10, 2018
Kind
B2
Abstract

The present invention is directed to a method of treating or preventing an addictive behavior in a subject, said method comprising administering to said subject an effective amount of a dopamine antagonist and a opiate receptor antagonist or a composition comprising same. Further provided are pharmaceutical compositions comprising, as active substances, at least one dopamine antagonist and at least one opiate receptor antagonist.

Claims (4)

1. A pharmaceutical composition consisting of, as active, synergistic substances:

levo-tetrahydropalmatine; and

naltrexone in an amount of about 0.01 mg/kg/dose to about 0.1 mg/kg/dose.

2. The composition of claim 1 , wherein said composition is formulated as levo-tetrahydropalmatine:naltrexone at a ratio of 10:1 to 50:1.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 28, 2013
From: WANG, JAI-BEI; SUSHCHYK, SARAH
To: UNIVERSITY OF MARYLAND, BALTIMORE
Reel/Frame 031487/0871 →
CONFIRMATORY LICENSE Recorded Sep 27, 2013
From: THE UNIVERSITY OF MARYLAND, BALTIMORE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 031303/0518 →
Continuity (2)
Provisional Application 61700591 · Sep 13, 2012
Related Publication 20140073664A1 · Mar 13, 2014