Skin external composition comprising a combination of sodium chloride and glucose as active ingredients for treating vaginosis and the use thereof
The present invention relates to a skin external composition comprising a combination of salt and sugar as an active ingredient in an amount effective to treat and prevent vaginosis, together with a pharmaceutically acceptable carrier, and the use thereof.
1. A method of treatment comprising administering to a mammal in need of treatment for a bacterial vaginosis infection a composition, wherein the composition is placed in a vagina of the mammal and the composition comprises:
sodium chloride and glucose; wherein the sodium chloride and glucose are 20 to 99.99% by weight of the composition and wherein the weight ratio of sodium chloride to glucose is 1:1-1:30, and
wherein the bacterial vaginosis infection is a Gardnerella vaginalis infection.
2. The method according to claim 1 , wherein the composition further comprises a liquid selected from the group consisting of distilled water, a buffered solution, an isotonic solution, a physiological saline, an oil, propylene glycol, ethanol and isopropyl myristate.
3. The method according to claim 1 , wherein the treatment is selected from the group consisting of alleviation of the Gardnerella vaginalis infection and elimination of the Gardnerella vaginalis infection.
4. The method according to claim 1 , wherein administering to the mammal comprises administering an amount of the composition ranging from 0.001 mg to 1000 mg per kilogram of body weight of the mammal.
5. The method according to claim 4 , wherein the amount of the composition ranges from 0.01 mg to 100 mg per kilogram of body weight of the mammal.
6. The method according to claim 1 , wherein the composition is administered from once a day to several times per day.
7. The method according to claim 1 , wherein the composition is selected from the group consisting of a topical preparation and an insert preparation.
8. The method according to claim 7 , wherein the topical preparation is selected from the group consisting of a cleansing liquid, a gel, a jelly, a foam, a cream, an ointment, a lotion, a balm, a patch, a paste, a spray solution and an aerosol.
9. The method according to claim 8 wherein the topical preparation a cleansing liquid.
10. The method according to claim 7 , wherein the insert preparation is selected from the group consisting of a tablet, a capsule, a film, a sponge, a tampon, and a pad.
11. The method according to claim 10 wherein the insert preparation is a tablet.
12. The method of claim 1 , wherein the composition further comprises a compound selected from the group consisting of an antibiotic, a dye, and flavor at a concentration from 0.1% to 20% by weight of the composition.