IP Library › Granted Patent US 8,858,938
Granted Patent B2
US 8,858,938 · App. 14/026,142 · Granted Oct 14, 2014

Human monoclonal antibodies against Hendra and Nipah viruses

Inventors: Dimiter S. Dimitrov (Rockville, MD); Zhongyu Zhu (Frederick, MD); Christopher C. Broder (Silver Spring, MD)
Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services; The Henry M. Jackson Foundation of the Advancement of Military Medicine, Inc.
C07K16/1027C07K2317/92C07K2316/96C07K2317/21C07K2317/565G01N33/6893
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Quick Facts
Patent No.
US 8,858,938
App. No.
14/026,142
Granted
Oct 14, 2014
Kind
B2
Abstract

The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus. The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah virus-binding ability, fully human antibodies retaining Hendra or Nipah virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.

Claims (2)

1. An antibody comprising the full-length antibody sequence produced by the cells deposited as American Type Culture Collection (ATCC) Deposit Number PTA-13287.

2. A pharmaceutical composition comprising the antibody of claim 1 and a pharmaceutically acceptable carrier.

Assignments (4)
CONFIRMATORY LICENSE Recorded Feb 23, 2017
From: HENRY M. JACKSON FDN FOR THE ADV MIL/MED
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 041787/0355 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 13, 2013
From: BRODER, CHRISTOPHER
To: UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES
Reel/Frame 031202/0494 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 13, 2013
From: UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES
To: THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
Reel/Frame 031202/0584 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 13, 2013
From: DIMITROV, DIMITER S.; ZHU, ZHONGYU
To: GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE
Reel/Frame 031202/0620 →
Continuity (7)
Continuation 13671721 · Nov 8, 2012
Division 13195366 · Aug 1, 2011
Division 11886307
Provisional Application 60661766 · Mar 14, 2005
Provisional Application 60678547 · May 5, 2005
Provisional Application 60718902 · Sep 20, 2005
Related Publication 20140079715A1 · Mar 20, 2014