IP Library › Granted Patent US 9,243,229
Granted Patent B2
US 9,243,229 · App. 14/028,808 · Granted Jan 26, 2016

Synthetic surfaces for culturing stem cell derived cardiomyocytes

Inventors: Christopher Bankole Shogbon (Corning, NY); Yue Zhou (Horseheads, NY); Ralph Brandenberger (Palo Alto, CA)
Assignee: Asterias Biotherapeutics, Inc.
C12N5/0657C12N5/0068C12N2500/90C12N2506/02C12N2533/30
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Quick Facts
Patent No.
US 9,243,229
App. No.
14/028,808
Granted
Jan 26, 2016
Kind
B2
Abstract

Synthetic surfaces suitable for culturing stem cell derived cardiomyocytes contain acrylate polymers formed from one or more acrylate monomers. The acrylate surfaces, in many cases, are suitable for culturing stem cell derived cardiomyocytes in chemically defined media.

Claims (6)

1. A cell culture comprising a beating cell expressing Nkx2.5 disposed on a surface comprising a diacrylate or a dimethacrylate.

2. The cell culture of claim 1 wherein the beating cell expressing Nkx2.5 is derived from a culture of pluripotent stem cells.

3. The cell culture of claim 1 , wherein the beating cell expressing Nkx2.5 is a human cell.

4. The cell culture of claim 1 , wherein the dimethacrylate is glycerol dimethacrylate.

5. The cell culture of claim 1 , wherein the diacrylate is poly(ethylene glycol) diacrylate.

6. The cell culture of claim 1 , wherein the dimethacrylate is 1,4-butanediol dimethacrylate.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 12, 2013
From: GERON CORPORATION
To: ASTERIAS BIOTHERAPEUTICS, INC.
Reel/Frame 031620/0567 →
Continuity (4)
Continuation 13546381 · Jul 11, 2012
Division 12362190 · Jan 29, 2009
Provisional Application 61062921 · Jan 30, 2008
Related Publication 20140134725A1 · May 15, 2014