Antifungal Treatment
A method of treating or preventing fungal infection, which includes identifying a plant or animal having a fungal infection and administering an effective amount of an anti-fungal composition to the plant or animal to reduce the fungal infection. In a preferred form of the present invention, the antifungal composition is compound 13 or 33 and is combined with an azole compound, such as fluconazole.
1 . A method for treating fungal infection, comprising:
(a) identifying a plant or animal having a fungal infection; and
(b) administering an effective amount of an anti-fungal compound to the plant or animal, wherein the amount is effective to reduce the fungal infection and wherein the compound comprises formula IV.
2 . The method of claim 1 wherein the compound comprises a compound of formula (IV):
wherein is an alkane, alkene, or alkyne, and R 5 is selected from the group consisting of formulas (V), (VI), (VII), and (VIII):
or a salt, prodrug, solvate or hydrate thereof.
3 . The method of claim 2 wherein the compound further comprises a compound of formula (I):
wherein R 1 is >S or oxidized >S, R 2 and R 3 are independently selected from formulas (II) and (III):
and R 4 is >S or oxidized >S, or a salt, prodrug, solvate or hydrate thereof.
4 . The method of claim 1 wherein the histidine kinase-dependent anti-fungal compound comprises:
or a salt, prodrug, solvate or hydrate thereof.
5 . The method of claim 4 wherein the histidine kinase-dependent anti-fungal compound further comprises:
or a salt, prodrug, solvate or hydrate thereof.
6 . The method of claim 1 additionally comprising administering an amount of an azole compound effective to reduce fungal infection.
7 . The method of claim 6 wherein the azole is fluconazole.
8 . The method of claim 1 , wherein the compound is a histidine kinase-dependent antifungal compound.
9 . The method of claim 8 , wherein the histidine kinase is Drk1.
10 . A method for preventing a fungal infection, comprising:
administering an effective amount of a composition of formula IV to a plant or animal,
wherein the amount is effective to prevent a fungal infection.
11 . The method of claim 10 wherein the composition comprises a compound of formula (IV):
wherein is an alkane, alkene, or alkyne, and R 5 is selected from the group consisting of formulas (V), (VI), (VII), and (VIII):
or a salt, prodrug, solvate or hydrate thereof.
12 . The method of claim 11 wherein the composition further comprises a compound of formula (I):
wherein R 1 is >S or oxidized >S, R 2 and R 3 are independently selected from formulas (II) and (III):
and R 4 is >S or oxidized >S, or a salt, prodrug, solvate or hydrate thereof.
13 . The method of claim 10 wherein the composition comprises:
or a salt, prodrug, solvate or hydrate thereof.
14 . The method of claim 10 wherein the composition further comprises:
or a salt, prodrug, solvate or hydrate thereof.
15 . The method of claim 10 additionally comprising administering an amount of an azole compound effective to reduce fungal infection.
16 . The method of claim 10 wherein the azole is fluconazole.
17 . A pharmaceutical dosage form comprising an effective amount of the compound of claim 1 and a pharmaceutically suitable carrier system.
18 . The dosage form of claim 17 wherein the compound comprises a compound of formula (IV):
wherein is an alkane, alkene, or alkyne, and R 5 is selected from the group consisting of formulas (V), (VI), (VII), and (VIII):
or a salt, prodrug, solvate or hydrate thereof.
19 . The dosage form of claim 17 , wherein the dosage form comprises an oral, injection, infusion, inhalation, transdermal, or implant dosage form.
20 . The dosage form of claim 17 wherein the compound further comprises a compound of formula (I):
wherein R 1 is >S or oxidized >S, R 2 and R 3 are independently selected from formulas (II) and (III):
and R 4 is >S or oxidized >S, or a salt, prodrug, solvate or hydrate thereof.
21 . The dosage form of claim 18 additionally comprising an azole compound.
22 . The dosage form of claim 20 additionally comprising an azole compound.
23 . An agricultural preparation comprising the compound of claim 1 .
24 . The preparation of claim 23 wherein the compound comprises a compound of formula (IV):
wherein is an alkane, alkene, or alkyne, and R 5 is selected from the group consisting of formulas (V), (VI), (VII), and (VIII):
or a salt, prodrug, solvate or hydrate thereof.
25 . The preparation of claim 23 wherein the compound further comprises a compound of formula (I):
wherein R 1 is >S or oxidized >S, R 2 and R 3 are independently selected from formulas (II) and (III):
and R 4 is >S or oxidized >S, or a salt, prodrug, solvate or hydrate thereof.