Compositions and methods for controlling infections
The invention features methods of inhibiting the growth of, or killing, fungal and certain bacterial microorganisms with one or more of a family of glycerol-based compounds.
1. A method of treatment or prophylaxis of a bacterial vaginosis infection in a subject in need thereof, comprising: administering to the subject a composition comprising an effective amount of glycerol monolaurate as the sole active agent, and one or more pharmaceutical excipients, wherein the glycerol monolaurate is administered to the subject at a dosage of 0.0001-100 mg/kg.
2. The method of claim 1 , wherein the bacterial vaginosis infection is selected from the group consisting of a Gardnerella vaginalis, Bacteroides bacteria, Prevotella melaninogenica, Prevotella species, Atopobium bacteria, Mobiluncus bacteria, and Peptostreptococcus bacteria.
3. The method of claim 2 , wherein the bacterial infection is a Bacteroides bacteria infection.
4. The method of claim 2 , wherein the bacterial infection is a Prevotella melaninogenica infection.
5. The method of claim 1 , wherein the subject is a vertebrate.
6. The method of claim 5 , wherein the vertebrate is a mammal.
7. The method of claim 6 , wherein the mammal is a human.
8. The method of claim 1 , wherein the one or more pharmaceutical excipients comprises ethylenediaminetetraacetic acid (EDTA).
9. The method of claim 1 , wherein the one or more pharmaceutical excipients comprises ascorbic acid.
10. The method of claim 1 , wherein the one or more pharmaceutical excipients comprises propylene glycol.
11. The method of claim 1 , wherein the one or more pharmaceutical excipients comprises polyethylene glycol.
12. The method of claim 2 , wherein the bacterial vaginosis infection comprises a Mobiluncus curtissi bacteria infection.