ORAL REHYDRATION COMPOSITION
Disclosed are oral rehydration compositions with sucrose, or alternatively fructose and glucose in a 1:1 ratio. The compostion further comprises an osmolarity of below 250 mOsm/L, and sodium below 75 meq/L. Further disclosed are methods of treatment using the same.
1 . An oral rehydration composition, comprising:
a) at least 40% w/w sucrose;
b) between 1% w/w and 3.5% w/w sodium;
c) between 0.1% w/w chloride and less than 1.5% w/w chloride;
d) potassium, at a level less than 5% w/w;
e) between 15% w/w and 30% w/w citric acid or citrate; and
f) glucose, at a level less than 0.5% w/w;
wherein the composition has a w/w ratio of sodium ions to chloride ions of at least 1.5:1, and wherein, upon mixture with an effective amount of water, the composition has an osmolarity of between 230 mOsm/L and 240 mOsm/L.
2 . (canceled)
3 . (canceled)
4 . (canceled)
5 . (canceled)
6 . The oral rehydration composition of claim 1 , comprising about 1400 mmol/L sucrose upon mixture with an effective amount of water.
7 . (canceled)
8 . (canceled)
9 . (canceled)
10 . (canceled)
11 . (canceled)
12 . The oral rehydration composition of claim 1 , comprising a ratio of sodium ions to chloride ions of 7:1.
13 . (canceled)
14 . The oral rehydration composition of claim 1 , comprising glucose in an amount less than 0.1% w/w.
15 . The oral rehydration composition of claim 1 , further comprising fructose in an amount less than 20% w/w.
16 . (canceled)
17 . (canceled)
18 . A method of treating or preventing dehydration in a subject in need thereof, comprising administering to the subject a composition of claim 1 .
19 . The method of claim 18 , wherein the subject is an athlete or a child.
20 . The method of claim 18 , wherein the subject is suffering from diarrhea.
21 . The method of claim 18 , wherein the subject is suffering from cholera.
22 . The method of claim 18 , wherein the subject is suffering from Short Bowel Syndrome.
23 . The method of claim 18 , wherein the subject is suffering from dehydration associated with excessive alcohol consumption.
24 . The oral rehydration composition of claim 1 , comprising less than 3% w/w sodium.
25 . The oral rehydration composition of claim 1 , comprising less than 20% w/w citric acid or citrate.
26 . The oral rehydration composition of claim 1 , comprising between 0.1% w/w chloride and 0.7% w/w chloride.
27 . The oral rehydration composition of claim 1 , comprising between 0.1% w/w chloride and 0.66% w/w chloride.