IP Library › Granted Patent US 9,433,705
Granted Patent B2
US 9,433,705 · App. 14/036,586 · Granted Sep 6, 2016

Methods for making oxidation-resistant cross-linked polymeric materials

Inventors: Orhun K. Muratoglu (Cambridge, MA); Edward T. Kopesky (Arlington, MA); Ebru Oral (Newton, MA)
Assignees: The General Hospital Corp.; Cambridge Polymer Group, Inc.
A61L27/505A61L27/16B29C43/003B29C71/04C08F10/02C08F110/02
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Quick Facts
Patent No.
US 9,433,705
App. No.
14/036,586
Granted
Sep 6, 2016
Kind
B2
Abstract

The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (α-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (α-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.

Claims (33)

1. A method of making an oxidation-resistant cross-linked polymeric material comprising the steps of:

a) blending a polymeric material with an antioxidant, wherein a first portion of the polymeric material is contacted with a concentration of an antioxidant, a second portion of the polymeric material is contacted with another concentration of the antioxidant, and a third portion of the polymeric material is contacted with another concentration of the antioxidant;

b) consolidating the antioxidant-blended polymeric material by layering the third portion of the polymeric material, the second portion of the polymeric material, and the first portion of the polymeric material, thereby forming an antioxidant-blended consolidated polymeric material; and

c) irradiating the antioxidant-blended consolidated polymeric material with ionizing radiation, thereby forming an oxidation-resistant cross-linked consolidated polymeric material.

2. A method of making a medical implant preform comprising an oxidation-resistant cross-linked polymeric material, wherein the method comprising the steps of:

a) blending a polymeric material with an antioxidant, wherein a first portion of the polymeric material is contacted with a concentration of an antioxidant, a second portion of the polymeric material is contacted with another concentration of the antioxidant, and a third portion of the polymeric material is contacted with another concentration of the antioxidant;

b) consolidating the antioxidant blended polymeric material by layering the third portion of the polymeric material, the second portion of the polymeric material, and the first portion of the polymeric material, thereby forming a medical implant preform; and

c) irradiating the medical implant preform containing the antioxidant blended polymeric material with ionizing radiation, thereby forming a medical implant preform having an oxidation-resistant cross-linked polymeric material.

3. The method according to claim 2 , wherein the polymeric material is polymeric resin powder, polymeric flakes, polymeric particles, or the like, or a mixture thereof.

4. The method according to claim 2 , wherein the antioxidant is vitamin E.

5. The method according to claim 2 , wherein the blended polymeric material in the first or the second portion, in the surface or in the bulk of the polymeric material contains different concentration of the antioxidant.

6. The method according to claim 2 , wherein the blended polymeric material in the first and second portions contain same concentrations of the antioxidant.

7. The method according to claim 2 , wherein the blended polymeric material in the second and third portions contain same concentrations of the antioxidant.

8. The method according to claim 2 , wherein the blended polymeric material in the first and third portions contain different concentrations of the antioxidant.

9. The method according to claim 2 , wherein the blended polymeric material in the first and third portions contain same concentrations of the antioxidant.

10. The method according to claim 2 , wherein the irradiated medical implant preform contains spatially distributed antioxidant and forms a medical implant preform having an oxidation-resistant cross-linked polymeric material having a spatially controlled cross-linking and antioxidant distribution.

11. The method according to claim 2 , wherein the irradiation is carried out at a temperature that is above the room temperature and below the melting point of the polymeric material, wherein the temperature is between about 40° C. and about 135° C.

12. The method according to claim 2 , wherein the medical implant preform is a direct compression molded implant.

13. A method of making an interlocked hybrid material comprising an oxidation-resistant cross-linked polymeric material, wherein the method comprising the steps of:

a) blending a polymeric material with an antioxidant, wherein a first portion of the polymeric material is contacted with a concentration of an antioxidant, a second portion of the polymeric material is contacted with another concentration of the antioxidant, and a third portion of the polymeric material is contacted with another concentration of the antioxidant;

b) compression molding the antioxidant blended polymeric material to another piece or a medical implant by layering the third portion of the polymeric material, the second portion of the polymeric material, and the first portion of the polymeric material, thereby forming an interface and an interlocked hybrid material; and

c) irradiating the interlocked hybrid material containing the antioxidant with ionizing radiation, thereby forming an interlocked hybrid material having an oxidation-resistant cross-linked polymeric material.

14. The method according to claim 13 , wherein the blended polymeric material in the first and second portions contain same concentrations of the antioxidant.

15. The method according to claim 13 , wherein the blended polymeric material in the second and third portions contain same concentrations of the antioxidant.

16. The method according to claim 13 , wherein the blended polymeric material in the first and third portions contain different concentrations of the antioxidant.

17. The method according to claim 13 , wherein the blended polymeric material in the first and third portions contain same concentrations of the antioxidant.

18. The method according to claim 13 , wherein the irradiated interlocked hybrid material contains spatially distributed antioxidant and forms an interlocked hybrid material having an oxidation-resistant cross-linked polymeric material having a spatially controlled cross-linking and antioxidant distribution.

19. The method according to claim 13 , wherein the another piece onto which the resins, flakes or powders are consolidated is a porous metal.

20. The method according to claim 13 , wherein the irradiation is performed when the interlocked hybrid material is at a temperature above room temperature and below the melting point of the polymeric material, wherein the temperature is between about 40° C. and about 135° C.

21. The method according to claim 13 , wherein the oxidation-resistant interlocked hybrid material is machined, thereby forming oxidation-resistant medical implant.

22. The method according to claim 21 , wherein the oxidation-resistant medical implant having a spatially controlled crosslinking and antioxidant distribution is packaged and sterilized.

23. The method according to claim 13 , wherein the interlocked hybrid material is a direct compression molded implant.

24. The method according to claim 13 , wherein the antioxidant is vitamin E.

Continuity (6)
Continuation 13562867 · Jul 31, 2012
Continuation 12522728
Provisional Application 60892346 · Mar 1, 2007
Provisional Application 60889037 · Feb 9, 2007
Provisional Application 60886527 · Jan 25, 2007
Related Publication 20140097559A1 · Apr 10, 2014