IP Library Granted Patent US 8,921,054
Granted Patent B2
US 8,921,054 · App. 14/037,652 · Granted Dec 30, 2014

Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions

Inventor: Joan M. Fallon (Bronxville, NY)
Assignee: Curemark, LLC
G01N33/56983C12Q1/6883C12Q1/689C12Q1/6893C12Q1/6895G01N33/569G01N33/56905G01N33/56911
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Quick Facts
Patent No.
US 8,921,054
App. No.
14/037,652
Granted
Dec 30, 2014
Kind
B2
Abstract

Methods for aiding in the diagnosis of disorders including, but not limited to, PDDs (Pervasive Development Disorders), Dysautonomic disorders, Parkinson's disease and SIDS (Sudden Infant Death Syndrome). In one aspect, a diagnosis method comprises analyzing a stool sample of an individual for the presence of a biological marker (or marker compound) comprising one or more pathogens, which provides an indication of whether the individual has, or can develop, a disorder including, but not limited to, a PDD, Dysautonomia, Parkinsons disease and SIDS. Preferably, the presence of one or more pathogens is determined using a stool immunoassay to determine the presence of antigens in a stool sample, wherein such antigens are associated with one or more pathogens including, but not limited to, Giardia, Cryptosporidium, E. histolytica, C. difficile , Adenovirus, Rotavirus or H. pylori.

Claims (10)

1. A method for determining if an individual has, or can develop, Attention Deficit Disorder (ADD) or Attention Deficit Hyperactive Disorder (ADHD), comprising the steps of:

analyzing a stool sample obtained from the individual with a stool immunoassay for the presence or absence an antigen associated with a pathogen, wherein the pathogen comprises Helicobacter pylori, Cryptosporidium, Entamoeba histolytica, Giardia , Rotavirus, Camphylobacter or Clostridium difficile;

detecting the level of chymotrypsin present in the stool sample, wherein the presence of the antigen and an abnormally low level of chymotrypsin in the stool sample allow for a determination that the individual has, or can develop, ADD or ADHD.

2. The method of claim 1 , wherein the presence of the pathogen in the stool sample is determined using stool immunoassay.

3. The method of claim 1 , wherein the pathogen comprises Helicobacter pylori.

4. The method of claim 1 , wherein the pathogen comprises Clostridium difficile.

5. The method of claim 1 , wherein the pathogen comprises Cryptosporidium.

6. The method of claim 1 , wherein the pathogen comprises Giardia.

7. The method of claim 1 , wherein the pathogen comprises Rotavirus or Adenovirus.

8. The method of claim 1 , wherein the pathogen comprises Entamoeba histolytica.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 21, 2013
From: FALLON, JOAN M.
To: CUREMARK, LLC
Reel/Frame 031446/0945 →
Continuity (4)
Division 13208963 · Aug 12, 2011
Division 09990909 · Nov 16, 2001
Provisional Application 60249239 · Nov 16, 2000
Related Publication 20140170637A1 · Jun 19, 2014