Estrogen receptor ligands and methods of use thereof
The present invention relates to methods of treating androgen deprivation therapy (ADT) induced hot flashes and severe hot flashes in a subject.
1. A compound, or a pharmaceutically acceptable salt thereof, wherein said compound is:
2. The compound of claim 1 , wherein said pharmaceutically acceptable salt is a bisulfate, borate, bromide, chloride, hemisulfate, hydrobromate, hydrochlorate, hydroxyethylsulfonate, iodate, iodide, isothionate, nitrate, persulfate, phosphate, sulfate, sulfamate, sulfanilate, sulfonic acid, sulfonate or thiocyanate, acetate, oxalate, tartrate, mandelate, citrate, sodium, potassium, ammonium, calcium, trimethylamine, or procaine.
3. The compound of claim 1 , wherein said pharmaceutically acceptable salt is a hydrochloride salt.
4. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a suitable carrier or diluent.
5. The pharmaceutical composition of claim 4 , wherein the pharmaceutical composition is in a liquid form for intravenous, intraarterial or intramuscular injection to a subject.
6. The pharmaceutical composition of claim 4 , wherein the pharmaceutical composition is for subcutaneous implantation in a subject.
7. The pharmaceutical composition of claim 4 , wherein the pharmaceutical composition is in a liquid or solid form for oral administration to a subject.
8. The pharmaceutical composition of claim 4 , wherein the pharmaceutical composition is for topical application to the skin surface of a subject.
9. The pharmaceutical composition of claim 4 , wherein the pharmaceutical composition is a tablet, a capsule, a solution, a suspension, an emulsion, an elixir, a gel, a suppository or a parenteral formulation.
10. The pharmaceutical composition of claim 4 , wherein said pharmaceutical composition is a patch.