Microencapsulated amino acid composition and the method of manufacturing the microencapsulated amino acid composition
The invention relates to a microencapsulated amino acid composition and methods of manufacturing this composition. Amino acids, such as branched-chain amino acids, have low water solubility, poor hydrophilicity, and poor stability. Amino acids are thus difficult to be digested and absorbed. Consequently amino acids can hardly meet human needs of consuming. This microencapsulated amino acid composition that can quickly disperse and dissolve in cold water, resulting clear solution. The method includes (1) adding coating agents, wetting agents, or other excipients to the amino acid mixture, (2) modifying the surface of microencapsulated particles to considerably accelerate the wetting speed. In this composition, the weight ratio of amino acids and excipients is from 100/0.1 to 100/10.0.
1. Granules of amino acid composition, consisting of a homogenous mixture of:
(a) one or more amino acids that consists of leucine, isoleucine, valine, or mixtures thereof;
(b) one or more coating agents and one or more wetting agents; and
(c) water,
wherein the granules of amino acid composition are obtained by spray-drying or extruding followed by drying and griddling the homogenous mixture so that the component (a) and the component (b) are mixed and homogenously distributed throughout the granules, including the entire surface thereof,
wherein the one or more coating agents are chosen from gum Arabic, sodium carboxy methyl starch, hydroxypropyl methylcellulose, or mixtures thereof,
wherein the one or more wetting agents are chosen from phospholipids, sucrose fatty acid ester, or mixtures thereof, and
wherein the granules, upon oral administration, are perceived to taste significantly better than the raw amino acids.
2. The granules of amino acid composition of claim 1 , wherein the weight ratio of the component (a) to the component (b) ranges from 100/0.1 to 100/10.
3. The granules of amino acid composition of claim 1 , wherein the composition has a water dispersion of less than 20 seconds.
4. A method of manufacturing the granules of amino acid composition of claim 1 , comprising:
A. mixing water or ethanol with the component (b) to get mixture I;
B. mixing the mixture I with the component (a) to get mixture II;
C. granulating the mixture II in a granulator; and
D. drying granules from the granulator.
5. The granules of amino acid composition of claim 1 , wherein the composition has a water-dissolved clearness time of less than 10 minutes.
6. The granules of amino acid composition of claim 1 , wherein the composition has a water solution turbidity of less than 30 NTU.
7. The granules of amino acid composition of claim 1 , wherein the one or more amino acids are in free form.