IP Library › Granted Patent US 9,200,015
Granted Patent B2
US 9,200,015 · App. 14/052,994 · Granted Dec 1, 2015

Inositol hexakisphosphate analogs and uses thereof

Inventors: Tor C. Savidge (League City, TX); Petril Urvil (Galveston, TX); Dhananjaya Nauduri (Galveston, TX); Numan Oezguen (Galveston, TX); Catherine Schein (Friendswood, TX); Werner Braun (Friendswood, TX)
Assignee: The Board of Regents of the University of Texas Systems
C07F9/117C07F9/06C07F9/177C07F9/70
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Quick Facts
Patent No.
US 9,200,015
App. No.
14/052,994
Granted
Dec 1, 2015
Kind
B2
Abstract

Provided herein are analog and derivative compounds of inositol hexakisphosphate effective to treat a Clostridium difficile infection and to neutralize the bacterial toxins produced by the same. In addition, methods of treating the C. difficile infection and for neutralizing its toxins with the compounds are provided.

Claims (6)

1. A method for neutralizing a Clostridium difficile bacterial toxin, comprising contacting the C. difficile bacterial toxin with an inositol hexakisphosphate analog having a chemical structure of Formula I:

wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are —PS(OH) 2 .

2. The method of claim 1 , wherein the Clostridium difficile bacterial toxin is TcdA, TcdB, or TcdA and TcdB.

3. The method of claim 1 , wherein the C. difficile bacterial toxin is in a subject having a Clostridium difficile infection.

4. The method of claim 3 , wherein the analog is administered orally to the subject.

5. The method of claim 1 , wherein nitric oxide (NO) is bound to at least one of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 .

Assignments (2)
CONFIRMATORY LICENSE Recorded Jun 21, 2017
From: UNIVERSITY OF TEXAS MEDICAL BR GALVESTON
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 042932/0920 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 6, 2015
From: SAVIDGE, TOR C.; URVIL, PETRI; NAUDURI, DHANANJAYA; OEZGUEN, NUMAN; SCHEIN, CATHERINE; BRAUN, WERNER
To: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 037219/0303 →
Continuity (3)
Division 13441017 · Apr 6, 2012
Provisional Application 61516639 · Apr 6, 2011
Related Publication 20140045799A1 · Feb 13, 2014