Compositions Comprising Peroxyacid and Methods for Producing and Using the Same
The present invention provides methods for producing a non α-keto peracid that has lower toxicity and lower corrosivity. The present embodiments also provide methods and compositions for reducing microbes on a surface, methods and compositions for preventing and reducing infectious vegetative bacteria on a substrate, and methods and compositions for treating a wound. In particular, compositions of the invention provide for a mixture of an α-keto peracid and a non α-keto peracid that works synergistically to reduce microbes on a surface, to prevent vegetative bacteria on a surface and to heal a wound in animals or humans.
1 . A method for producing a composition comprising a non α-keto peracid and an α-keto peracid, the method comprising:
contacting an α-keto carboxylic acid with an oxidizing agent under conditions sufficient to produce the α-keto peracid; and
contacting an α-keto carboxylic acid with an oxidizing agent under conditions sufficient to produce the non α-keto peracid.
2 . The method of claim 1 , wherein the oxidizing agent is selected from the group consisting of hydrogen peroxide, barium peroxide, sodium carbonate peroxide, calcium peroxide, sodium perborate, lithium peroxide, magnesium peroxide, strontium peroxide, zinc peroxide, potassium superoxide, or a mixture thereof.
3 . The method of claim 1 , wherein the reaction temperature ranges from about −30° C. to about 10° C.
4 . The method of claim 1 , wherein the α-keto carboxylic acid comprises an α-keto monocarboxylic acid.
5 . The method of claim 1 , wherein the α-keto carboxylic acid comprises an α-keto dicarboxylic acid.
6 . The method of claim 1 , wherein the α-keto carboxylic acid is selected from the group consisting of pyruvic acid, α-keto butyric acid, α-keto valeric acid, α-keto glutaric acid. 2-oxo cylopental acetic acid, or a mixture thereof.
7 . The method of claim 1 , wherein the α-keto peracid and the non α-keto peroxyacid are further used in a synergistic combination to kill biofilms and microbes selected from the group consisting of bacterial spores, mycobacteria, gram-negative bacteria, vegetative gram-positive bacteria, fungus, viruses, or a combination thereof.
8 . A method for reducing the amount of microbe on a surface, said method comprising contacting the surface with an antimicrobial solution composition comprising an effective amount of a non α-keto peracid.
9 . The method of claim 8 , wherein the composition further comprises hydrogen peroxide.
10 . The method of claim 8 , wherein the composition further comprises an α-keto peracid.
11 .- 12 . (canceled)
13 . The method of claim 8 , wherein the non α-keto peracid is selected from the group consisting of peroxyformic, peroxyacetic, peroxypropionic, peroxybutanoic, peroxypentanoic, peroxyhexanoic, peroxyheptanoic, peroxyoctanoic, peroxynonanoic, peroxydecanoic, peroxyundecanoic, peroxydodecanoic, or the peroxyacids of their branched chain isomers, peroxylactic, peroxymaleic, peroxyascorbic, peroxyhydroxyacetic, peroxyoxalic, peroxymalonic, peroxysuccinic, peroxyglutaric, peroxyadipic, peroxypimelic, peroxysubric acid, and mixtures thereof.
14 .- 16 . (canceled)
17 . The method of claim 8 , wherein the non α-keto peracid is metabolically active.
18 . The method of claim 8 , wherein the non α-keto peroxyacids is used in a synergistic combination with an alpha keto peroxyacids.
19 .- 21 . (canceled)
22 . The method of claim 18 , wherein the synergistic combination of the t-alpha keto peracid and the non α-keto peroxyacid is used to kill biofilms and microbes selected from the group consisting of bacterial spores, mycobacteria, gram-negative bacteria, vegetative gram-positive bacteria, fungus, viruses, or a combination thereof.
23 . The method of claim 8 , wherein the antimicrobial solution further comprises hydrogen peroxide, ethyl alcohol, or other antimicrobial agents.
24 . (canceled)
25 . A method for treating a wound on a subject comprising contacting the wound with a therapeutically effective amount of a composition comprising an α-keto peracid and a non α-keto peracid solution.
26 .- 32 . (canceled)
33 . The method of claim 25 , wherein the non α-keto peroxyacids is used in a synergistic combination with the alpha keto peroxyacids.
34 . The method of claim 33 , wherein the synergistic combination of the non α-keto peroxyacids and the α-keto peroxyacids is used to kill biofilms and microbes selected from the group consisting of bacterial spores, mycobacteria, gram-negative bacteria, vegetative gram-positive bacteria, fungus, viruses, or a combination thereof.
35 .- 36 . (canceled)
37 . The method of claim 25 , wherein the composition further comprises hydrogen peroxide, ethyl alcohol, or other antimicrobial agents.
38 .- 39 . (canceled)
40 . An antimicrobial composition comprising a mixture of an α-keto peracid and a non α-keto peracid.