IP Library › Granted Patent US 9,353,152
Granted Patent B2
US 9,353,152 · App. 14/063,748 · Granted May 31, 2016

Induction of the mitochondrial permeability transition

Inventor: Philip John Hogg (Randwick, AU)
Assignee: NewSouth Innovations Pty Limited
C07K7/06A61K31/285C07F5/06C07F9/78C07F9/803C07F9/82C07K5/08G01N33/5011G01N33/5079G01N33/574G01N33/6872G01N2333/515G01N2500/10
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Quick Facts
Patent No.
US 9,353,152
App. No.
14/063,748
Granted
May 31, 2016
Kind
B2
Abstract

The present invention relates to process for identifying a compound which induces the mitochondrial permeability transition (MPT) in proliferating cells, wherein said process comprises contacting a cell or cell extract with a compound, determining whether the compound binds to adenine nucleotide translocator (ANT), and determining whether the compound selectively induces the MPT in proliferating cells.

Claims (3)

1. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a compound according to claim 1 together with a pharmaceutically acceptable carrier, adjuvant and/or diluent.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 4, 2013
From: HOGG, PHILIP JOHN
To: UNISEARCH LIMITED
Reel/Frame 031541/0080 →
CHANGE OF NAME Recorded Nov 4, 2013
From: UNISEARCH LTD.
To: NEWSOUTH INNOVATIONS PTY LIMITED
Reel/Frame 031579/0752 →
Priority Claims (2)
AU 2002952526 · Nov 7, 2002 · national
AU 2003906109 · Nov 5, 2003 · national
Continuity (2)
Continuation 10534922
Related Publication 20140121165A1 · May 1, 2014