Method of treating diseases that respond to therapy by dopamine or dopamine agonists
The invention relates to a medicament containing (S)-2-N-propylamino-5-hydroxytetralin, the salts or prodrugs thereof. As a D3 agonist, (S)-2-N-propylamino-5-hydroxytetralin is suitable particularly for the treatment of dopa-sensitive movement disorders.
1. A method for treating a disease that responds to therapy by dopamine or a dopamine agonist in a subject in need thereof, the method comprising administering to the subject (S)-2-N-propylamino-5-hydroxytetralin, a pharmaceutically acceptable salt of (S)-2-N-propylamino-5-hydroxytetralin or a prodrug of (S)-2-N-propylamino-5-hydroxytetralin, wherein the prodrug corresponds in structure to the following formula:
wherein R 1 is selected from the group consisting of acyl, alkoxycarbonyl, cycloalkoxycarbonyl, aryloxycarbonyl, acetal, ketal, —C(O)NR 2 R 3 —C(O)NHR 2 , —P(O 2 H)OR 2 and —P(O 2 H)R 2 , and
wherein R 2 and R 3 are independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 3-10 cycloalkyl, benzyl and phenyl, wherein the disease that responds to therapy by dopamine or a dopamine agonist is selected from the group consisting of depression, an anxiety disorder, a cognitive disorder, attention deficit hyperactivity syndrome (ADHS), restless leg syndrome, morbus Parkinson, a Parkinson-associated movement disorder, dyskinesia, dystonia, rigor and tremor.
2. The method of claim 1 , comprising administering to the subject (S)-2-N-propylamino-5-hydroxytetralin or a pharmaceutically acceptable salt thereof.
3. The method of claim 1 , comprising administering to the subject the prodrug of (S)-2-N-propylamino-5-hydroxytetralin, wherein R 1 is selected from the group consisting of C 1-6 alkylcarbonyl, C 3-10 cycloalkylcarbonyl, benzoyl, —C(O)NR 2 R 3 and —C(O)NHR 2 .
4. The method of claim 1 , wherein (S)-2-N-propylamino-5-hydroxytetralin, the pharmaceutically acceptable salt of (S)-2-N-propylamino-5-hydroxytetralin or the prodrug of (S)-2-N-propylamino-5-hydroxytetralin is present as a pure (S)-enantiomer.
5. The method of claim 1 , wherein (S)-2-N-propylamino-5-hydroxytetralin, the pharmaceutically acceptable salt of (S)-2-N-propylamino-5-hydroxytetralin or the prodrug of (S)-2-N-propylamino-5-hydroxytetralin is administered in a form selected from the group consisting of an infusion solution, an injection solution, an oily suppository, a patch, a microcapsule and a microparticle.
6. The method of claim 1 , further comprising administering to the subject a further active agent.
7. The method of claim 6 , wherein the further active agent is L-dopa.
8. The method of claim 6 , wherein (S)-2-N-propylamino-5-hydroxytetralin, the pharmaceutically acceptable salt of (S)-2-N-propylamino-5-hydroxytetralin or the prodrug of (S)-2-N-propylamino-5-hydroxytetralin and the further active agent are administered to the subject in the same or different application units and either together or separately.
9. The method of claim 6 , wherein (S)-2-N-propylamino-5-hydroxytetralin, the pharmaceutically acceptable salt of (S)-2-N-propylamino-5-hydroxytetralin or the prodrug of (S)-2-N-propylamino-5-hydroxytetralin and the further active agent are present in the same formulation or in different formulations.
10. The method of claim 1 , wherein (S)-2-N-propylamino-5-hydroxytetralin, the pharmaceutically acceptable salt of (S)-2-N-propylamino-5-hydroxytetralin or the prodrug of (S)-2-N-propylamino-5-hydroxytetralin is administered to the subject in an amount to achieve a plasma concentration of (S)-2-N-propylamino-5-hydroxytetralin of between 0.02 and 100 ng/ml.