IP Library › Granted Patent US 9,393,254
Granted Patent B2
US 9,393,254 · App. 14/067,084 · Granted Jul 19, 2016

Compositions of A-8R peptide

Inventors: Lirim Shemshedini (Ypsilanti, MI); Shao-Yong Chen (Brookline, MA); Changmeng Cai (Newton, MA); Chen-Lin Hsieh (Brighton, MA)
Assignee: The University of Toledo
A61K31/7048A61K38/08A61K38/10C07K7/06C07K7/08A61K38/00
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Quick Facts
Patent No.
US 9,393,254
App. No.
14/067,084
Granted
Jul 19, 2016
Kind
B2
Abstract

The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.

Claims (6)

1. A composition of matter comprising a peptide consisting of the amino acid sequence set forth in SEQ ID NO:1.

2. A pharmaceutical composition comprising:

a composition of claim 1 ; and

a composition selected from the group consisting of: an adjuvant, a pharmaceutically-acceptable salt, a prodrug, a buffer, and a biomarker.

3. A composition of claim 1 , which further comprises a chemotherapeutic agent.

4. A composition of claim 3 , wherein the chemotherapeutic agent is etoposide.

Assignments (2)
CONFIRMATORY LICENSE Recorded Mar 5, 2014
From: UNIVERSITY OF TOLEDO
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 032387/0542 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 30, 2013
From: SHEMSHEDINI, LIRIM; CHEN, SHAO-YONG; CAI, CHANGMENG; HSIEH, CHEN-LIN
To: THE UNIVERSITY OF TOLEDO
Reel/Frame 031512/0416 →
Continuity (3)
Division 13375307
Provisional Application 61182712 · May 30, 2009
Related Publication 20140057853A1 · Feb 27, 2014