Method and device for enhancing a directional migration of stem cells

1. A method of enhancing a directional migration of stem cells, comprising providing one or more stem cell(s) and irradiating the stem cells with an effective energy of green light thereby enhancing stem cell directionally migrating, wherein the orientation of migration of stem cells is opposite to the green light source.

2. The method of claim 1 , wherein the irradiation of green light is provided at an energy level of about 0.5 J/cm 2 to about 30 J/cm 2 .

3. The method of claim 1 , wherein the irradiation of green light is provided at an energy level of about 1.95 J/cm 2 to about 11.4 J/cm 2 .

4. The method of claim 1 , wherein the energy level is green light emitting diode (LED), green fluorescence or laser.

5. The method of claim 1 , wherein the stem cells are embryonic stem cells or adult stem cells.

6. The method of claim 5 , wherein the adult stem cell is hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs), adipose-derived stem cell, endothelial stem cell and dental pulp stem cells.

7. The method of Claim 6 , wherein the adipose-derived stem cell is orbital fat stem cell (OFSC).

8. A stem cell produced by the method of claim 1 , which has higher ATP contents then the stem cell untreated by the method of claims 1 and p38, ERK ½, c-Jun N-terminal kinase (JNK), MAP kinase kinase (MEK) ½, Akt, cAMP response element-binding (CREB), Yes and c-Jun are activated.

9. The cell of claim 8 , wherein Lyn, signal transducer and activator of transcription (STAT) 5 alpha, and p70S6 kinase are inhibited.

10. The cell of claim 8 , wherein the expression of RRH, OPN1SW and OPN3are induced by green light.