IP Library › Granted Patent US 9,221,888
Granted Patent B2
US 9,221,888 · App. 14/079,086 · Granted Dec 29, 2015

Bone substitute nanocomposites and methods of synthesis using multiphosphorylated peptides

Inventors: Elia Beniash (Pittsburgh, PA); Charles S. Sfeir (Pittsburgh, PA)
Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
C07K14/47A61L27/46A61L27/54C07K7/08A61K38/00A61L2300/25A61L2300/252A61L2430/02
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Quick Facts
Patent No.
US 9,221,888
App. No.
14/079,086
Granted
Dec 29, 2015
Kind
B2
Abstract

The invention relates to peptides including DEDE(SSD) n DEG indicated by SEQ NO. 1, RRRDEDE(SSD) n DEG indicated by SEQ No. 2, RRRGDEDE(SSD) n DEG indicated by SEQ No. 3, and LKKLKKLDEDE(SSD)nDEG indicated by SEQ NO. 4, wherein n is an integer from 2 to 20. The invention also relates to phosphorylating these peptides at multiple amino acid sites by employing casein kinases. These phosphorylated peptides may be used in various applications such as forming mineralized collagen fibrils and biomimetic composites for use in tissue repair and regeneration.

Claims (4)

1. A peptide, comprising:

RRRDEDE(SSD) n DEG, wherein n is an integer selected from 3 and 5, indicated by SEQ NO. 2.

2. A mineralized collagen fibril which comprises collagen fibrils, organized mineral crystals and the peptide of claim 1 to promote the organized mineralization of collagen fibrils.

3. A collagen scaffold which comprises the peptide of claim 1 .

Assignments (2)
CONFIRMATORY LICENSE Recorded May 27, 2015
From: UNIVERSITY OF PITTSBURGH
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 035782/0473 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 25, 2014
From: BENIASH, ELIA; SFEIR, CHARLES S.
To: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Reel/Frame 033176/0516 →
Continuity (2)
Provisional Application 61725796 · Nov 13, 2012
Related Publication 20150045304A1 · Feb 12, 2015