4′-O-substituted isoindoline derivatives and compositions comprising and methods of using the same
Provided are 4′-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
1. A compound of formula:
or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:
Y is C═O or CH 2 ; and
R 1 is alkyl substituted with one or more groups selected from alkoxy, halo, carboxy, alkylaminocarbonyl, alkoxycarbonyl, nitro, nitrile, haloalkyl, hydroxy, and alkylsulfonyl.
2. The compound of claim 1 , wherein Y is C═O.
3. The compound of claim 1 , wherein Y is CH 2 .
4. The compound of claim 1 , wherein the compound is:
5. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt, or stereoisomer thereof.