Therapeutic compounds
View Patent ↗The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C disorders, including diseases and disorders mediated by GPCRs.
1. A compound that is:
wherein,
R 1 is independently H, NH 2 , NH(alkyl), N(alkyl) 2 ;
R 2 is independently —(CH 2 )n-;
Each n is independently 1 or 2;
R 3 is independently H, OH, or halo;
R 4 is independently H, OH, or halo
R 5 is m-F, m-Cl, m-Br, m-Me, or m-OMe;
R 6 is independently H or alkyl; and
R 7 independently H, N(alkyl) 2 ;
or salt, hydrate or solvate thereof.
2. A composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
3. A method of making a composition of claim 2 comprising combining a compound of claim 1 and a pharmaceutically acceptable carrier.
4. The compound of claim 1 , wherein the compound is (−)-trans-4-(3-bromophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine.
5. The compound of claim 1 , according to the following formula:
wherein R is selected from the group consisting of
6. The compound of claim 1 , wherein the compound is (−)-trans-4-(3-chlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine.
7. The compound of claim 1 , wherein the compound is (−)-trans-4-(3-fluorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine.
8. The compound of claim 1 , wherein the compound is (−)-trans-4-(3-tolyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine.
9. The compound of claim 1 , wherein the compound is (−)-trans-4-(3-methoxyphenyl)-N,N-dimethyl-1,2,3,4-tetrahydronaphthalen-2-amine.