Methods for preparing oxazolidinones and compositions containing them
View Patent ↗Methods of preparing a class of oxazolidinones useful to impede bacterial growth are disclosed.
1. A compound of the formula:
wherein:
R 1 a and R 1 b are independently selected from H and F, provided that at least one of R 1 a and R 1 b is F,
R 2 is selected from the group consisting of optionally substituted benzyl and optionally substituted C 1 -C 6 alkyl, and
Het is tetrazolyl optionally substituted with methyl.
2. The compound of claim 1 wherein R 1 a is F and R 1 b is H.
3. The compound of claim 1 wherein Het is substituted with methyl.
4. The compound of claim 3 wherein Het is 2-methyl-tetrazol-5-yl.
5. The compound of claim 1 wherein R 2 is benzyl.
6. The compound of claim 1 wherein R 1 a is F, R 1 b is H, R 2 is benzyl, and Het is 2-methyl-tetrazol-5-yl.
7. The compound of claim 1 wherein the optionally substituted benzyl and the optionally substituted C 1 -C 6 alkyl are independently unsubstituted or substituted with halogen or C 1 -C 4 alkyloxy.