Inhibitors of the plasmodial surface anion channel as antimalarials
Disclosed are inhibitors of the plasmodial surface anion channel (PSAC) inhibitors and the use thereof in treating or preventing malaria in an animal such as a human, comprising administering an effective amount of an inhibitor or a combination of inhibitors. An example of such an inhibitor is a compound of formula I, or a pharmaceutically acceptable salt thereof, wherein R 1 to R 7 are as described herein.
1. A method of providing prophylaxis to an animal in need thereof against malaria or treating an animal afflicted with malaria comprising administering to the animal an effective amount of a compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the compound is:
3. The method of claim 1 , wherein the compound is:
4. The method of claim 1 , wherein the compound is:
5. The method of claim 1 , wherein the compound is:
6. The method of claim 1 , wherein the compound is
7. The method of claim 1 , wherein the compound
8. The method of claim 1 , wherein the compound is:
9. The method of claim 1 , wherein the compound is: