Kneadable and pliable bone replacement material
A kneadable and moldable bone-replacement material includes a mixture of calcium-containing ceramic particles and a hydrogel or a substance which can be swelled into a hydrogel. The ceramic particles are of fully synthetic origin and the individual ceramic particles have a structure which is at least partially cohesive and porous. In addition, the majority of the ceramic particles have a non-spheric shape.
1. A kneadable and moldable bone-replacement material which consists of a mixture of:
A) calcium-containing ceramic particles comprising pore size(s) from 100 to 500 micrometers;
B) a hydrogel or a substance that can be swelled into a hydrogel having a molecular weight greater than about 300,000 Daltons, and
wherein the ceramic particles are of fully synthetic origin; the individual ceramic particles have at least a partially cohesive, porous structure; and at least 60% of the ceramic particles have an angular shape, wherein the porosity of the ceramic particles is between 60 and 90 percent.
2. The bone-replacement material in accordance with claim 1 , wherein pore size of the ceramic particles is between 340 and 450 micrometers.
3. The bone-replacement material in accordance with claim 1 , wherein the bulk density of the ceramic particles is between 0.2 g/cm 3 and 2.0 g/cm 3 .
4. The bone-replacement material in accordance claim 1 , wherein the jarring density of the ceramic particles is between 0.5 g/cm 3 and 2.5 g/cm 3 .
5. The bone-replacement material in accordance with claim 1 , wherein the average diameter of the ceramic particles is between 100 and 250 micrometers.
6. The bone-replacement material in accordance with claim 1 , wherein the average diameter of the ceramic particles is between 250 and 500 micrometers.
7. The bone-replacement material in accordance with claim 1 , wherein the average diameter of the ceramic particles is between 0.5 and 5.6 mm.
8. The bone-replacement material in accordance with claim 1 , wherein ceramic particles with an average diameter of 100 to 250 micrometers are used together with those having an average diameter of 250 to 500 micrometers and/or together with those having an average diameter of 0.5 to 5.6 mm.
9. The bone-replacement material in accordance with claim 1 , wherein the ceramic particles consist of a calcium-phosphate having a molar Ca/P relationship between 1.0 and 2.0.
10. The bone-replacement material in accordance with claim 1 , wherein the ceramic particles consist of a mixture of different calcium-phosphates.
11. The bone-replacement material in accordance with claim 1 , wherein the ceramic particles consist of a calcium-sulfate.
12. The bone-replacement material in accordance with claim 1 , wherein the ceramic particles consist of a calcium-carbonate.
13. The bone-replacement material in accordance with claim 1 , wherein the ceramic particles consist of a mixture of different calcium-phosphates, calcium-sulfates and/or calcium-carbonates.
14. A kneadable and moldable bone-replacement material which consists of a mixture of:
A) calcium-containing ceramic particles comprising pore size(s) from 100 to 500 micrometers;
B) a hydrogel or a substance that can be swelled into a hydrogel having a molecular weight greater than about 300,000 Daltons, and
wherein the ceramic particles are of fully synthetic origin; the individual ceramic particles have at least a partially cohesive, porous structure; at least 60% of the ceramic particles have an angular shape, wherein the porosity of the ceramic particles is between 60 and 90 percent; and
C) metallic or semi-metallic ion shares as additives.
15. The bone-replacement material in accordance with claim 1 , wherein the hydrogel or the substance which can be swollen into a hydrogel consists of fully synthetic substances.
16. The bone-replacement material in accordance with claim 1 , wherein the hydrogel or the substance which can be swelled into a hydrogel consists of natural biological substances.
17. The bone-replacement material in accordance with claim 1 , wherein the hydrogel or the substance which can be swollen into a hydrogel consists of a biotechnologically generated substance.
18. The bone-replacement material in accordance with claim 1 , wherein the hydrogel is a liquid solution of a hyaluronate.
19. The bone-replacement material in accordance with claim 1 , wherein the weight relationship A/B between the hydrated hydrogel and the calcium-containing ceramic particles is between 0.2 and 5.