Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy
Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.
1. An apparatus for treating a neural condition of a patient, comprising:
an implantable stimulation lead configured to be positioned to apply electrical stimulation to neural tissue of the patient's nervous system, the implantable stimulation lead configured to be implanted in the patient; and
an implantable signal generator for generating electrical pulses, the implantable signal generator coupled to the implantable stimulation lead, wherein the implantable signal generator comprises a controller;
wherein the controller is configured to direct an application of electrical stimulation to the patient in a manner such that the stimulation has a burst frequency and an intra-burst frequency greater than the burst frequency, wherein the controller modifies a frequency parameter of the burst stimulation in response to administration of a motor-disorder drug by the patient.
2. The apparatus of claim 1 wherein the intra-burst frequency varies from burst to burst.
3. The apparatus of claim 1 wherein the burst frequency is generally similar to natural brainwaves.
4. The apparatus of claim 3 wherein the natural brainwaves are selected from a group consisting of alpha, beta, gamma, delta or theta.
5. The apparatus of claim 1 wherein the intra-burst frequency is about 50 Hz to about 500 Hz.
6. The apparatus of claim 1 wherein the stimulation is directed to different electrodes.
7. The apparatus of claim 1 wherein the stimulation is directed over different time domains.
8. An apparatus for treating a neural condition of a patient, comprising:
an implantable stimulation lead configured to be positioned to apply electrical stimulation to neural tissue of the patient's nervous system, the implantable stimulation lead configured to be implanted in the patient; and
an implantable signal generator for generating electrical pulses, the implantable signal generator coupled to the implantable stimulation lead, wherein the implantable signal generator comprises a controller;
wherein the controller is configured to direct an application of electrical stimulation to the patient in a manner such that the stimulation has a burst frequency and an intra-burst frequency greater than the burst frequency, wherein the controller modifies a frequency parameter of the burst stimulation in response to administration of a motor-disorder drug by the patient, wherein modification of the frequency parameter causes the implantable signal generator to temporarily apply reduced power for applied electrical stimulation.
9. The apparatus of claim 8 wherein the intra-burst frequency varies from burst to burst.
10. The apparatus of claim 8 wherein the burst frequency is generally similar to natural brainwaves.
11. The apparatus of claim 10 wherein the natural brainwaves are selected from a group consisting of alpha, beta, gamma, delta or theta.
12. The apparatus of claim 8 wherein the intra-burst frequency is about 50 Hz to about 500 Hz.
13. The apparatus of claim 8 wherein the stimulation is directed to different electrodes.
14. The apparatus of claim 8 wherein the stimulation is directed over different time domains.