17alfa, 21-dihydroxypregnene esters as antiandrogenic agents
17α,21-Dihydroxypregna-4,9(11)-diene-3,20-dione and 17α,21-dihydroxypregna-4-ene-3,20-dione 17 and/or 21 esters thereof having remarkable antiandrogenic activity, and the processes for the preparation thereof.
1. A method of treating a patient suffering from acne or alopecia comprising administering to said patient topically an effective amount of 17α-propionyloxy-21-hydroxy-pregna-4-ene-3,20-dione.
2. The method of claim 1 , wherein the patient suffers from acne.
3. The method of claim 1 , wherein the patient suffers from alopecia.
4. A method of treating a patient suffering from acne or alopecia comprising administering to said patient topically an effective amount of a pharmaceutical composition comprising 17α-propionyloxy-21-hydroxy-pregna-4-ene-3,20-dione.
5. The method of claim 4 , wherein the 17α-propionyloxy-21-hydroxy-pregna-4-ene-3,20-dione is present in the composition at a concentration of about 2 μg/μL to about 8 μg/μL.
6. The method of claim 4 , wherein the patient suffers from acne.
7. The method of claim 4 , wherein the patient suffers from alopecia.
8. The method of claim 4 , wherein the pharmaceutical composition is selected from the group consisting of a liposomal emulsion or suspension, a cream, and a gel.
9. The method of claim 8 , wherein the pharmaceutical composition is a cream.
10. The method of claim 9 , wherein the cream comprises cetyl alcohol, glycerol monostearate, liquid paraffin, propylene glycol, disodium mono-oleo-amido sulfosuccinate, citric acid monohydrate, and purified water.