Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing
Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing. Pharmaceutical composition containing antagonists. Methods employing antagonists and agonists for modulation of quorum sensing. Compounds are exemplified by those of formula: A-[Z] n -L1-[Y] q -W-[V] m -L2-HG, where A is an acyclic aliphatic group, and HG is an optionally substituted phenyl group. Compounds include those where m and n are both 0, W is —NH—, Y is present and is —CO—CH 2 —CO—, and L1 and L2 independently are —[CH 2 ] p1 — and —[CH 2 ] p2 —, where p1 and p2, independently, are 0 or integers ranging from 1-10.
1. A compound having formula:
A-CO—CH 2 —CO—NH—HG
wherein A is an unsubstituted alkyl group having 9 or 10 carbon atoms and HG is an unsubstituted phenyl group.
2. The compound of claim 1 wherein A is an unsubstituted straight-chain alkyl group having 9 carbon atoms.
3. A compound selected from:
4. A pharmaceutical composition comprising a quorum sensing antagonist of claim 1 in an amount effective for obtaining a therapeutic effect and a pharmaceutically acceptable carrier.
5. The composition of claim 4 further comprising an antimicrobial compound, an antibacterial compound, an antiviral agent or an antibiotic, other than a quorum sensing antagonist.
6. A method for inhibiting quorum sensing bacteria which comprising the step of contacting the quorum sensing bacteria with an amount of a quorum sensing compound of claim 1 effective for inhibition of quorum sensing.
7. The method of claim 6 wherein bacterial biofilm formation is disrupted which comprises the step of contacting the biofilm or an environment containing the biofilm with the compound of claim 1 .