Anti-malarial compounds from marine natural products
Novel compositions and methods for the treatment and prevention of malaria are disclosed herein.
1. A method for treating malaria in a subject comprising administering to a subject in need thereof an effective amount of a composition comprising a compound having one of the following structures:
or is an analog, combination, derivative, prodrug, stereoisomer, or pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein composition further comprises a pharmaceutically acceptable carrier.
3. The method of claim 1 , further comprising administering a conjunctive anti-malarial agent to the subject.
4. The method of claim 1 , wherein the compound of the composition comprises a ratio of a NIH 3T3 IC 50 μm value to a P. falciparum IC 50 μm value of at least 9:1.
5. A method for treating a condition in a subject in need, the method comprising administering to the subject an effective amount of a composition, wherein the condition comprises of a symptom of malaria; wherein the composition comprises a compound having one of the following structures:
or is an analog, combination, derivative, prodrug, stereoisomer, or pharmaceutically acceptable salt thereof.
6. The method of claim 5 , wherein composition further comprises a pharmaceutically acceptable carrier.
7. The method of claim 5 , further comprising administering a conjunctive anti-malarial agent to the subject.
8. The method of claim 5 , wherein the composition comprises a compound with the following structure:
or is an analog, derivative, prodrug, stereoisomer, or pharmaceutically acceptable salt thereof.
9. A method of treating malaria by killing or arresting the growth of F. Plasmodium in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition comprising a compound having one of the following structures:
or is an analog, combination, derivative, prodrug, stereoisomer, or pharmaceutically acceptable salt thereof.
10. The method of claim 9 , wherein composition further comprises a pharmaceutically acceptable carrier.
11. The method of claim 9 , further comprising administering a conjunctive anti-malarial agent to the subject.
12. The method of claim 9 , wherein the composition comprises a compound the following structure:
or is an analog, derivative, prodrug, stereoisomer, or pharmaceutically acceptable salt thereof.