Androgen receptor modulating carboxamides

1. A compound of formula (I) or (II)

wherein ring A is any one of the following groups or tautomers thereof

wherein

R X is halogen or CF 3 ;

R X is hydrogen or halogen;

R 1 is hydroxy C 3-7 alkyl, imidazolyl or —R A OC(O)—R B ;

R A is C 1-7 alkyl;

R B is C 1-7 alkyl, hydroxy C 1-7 alkyl or carboxy C 1-7 alkyl;

R 2 is C 1-7 alkyl, C 2-7 alkenyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl C 1-7 alkyl, methylpyrazolyl or pyrimidinyl;

R 3 is halogen or pyridinyl;

R 4 is pyridinyl;

R 5 is C 1-7 alkyl, C 2-7 alkenyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl C 1-7 alkyl, cyano, hydroxy C 1-7 alkyl, oxo C 1-7 alkyl, halogen or methylpyrazolyl;

R 6 is C 1-7 alkyl, C 2-7 alkenyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl C 1-7 alkyl, hydroxy, hydroxy C 1-7 alkyl, cyano C 1-7 alkyl or C 1-7 alkoxycarbamoyl C 1-7 alkyl;

R 7 is hydroxy C 4 alkyl;

R 8 is halogen, C 2-7 alkyl, C 2-7 alkenyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl C 1-7 alkyl, cyano, carboxy, oxo C 1-7 alkyl, halo C 1-7 alkyl, hydroxy C 1-7 alkyl, tetrahydro-2H-thiopyran or —C(O)—NHR 20 ;

R 9 is hydrogen, hydroxy, halogen, nitro, amino, cyano, oxo, C 1-7 alkyl, C 2-7 alkenyl, C 3-7 cycloalkyl, C 1-7 alkoxy, halo C 1-7 alkyl, hydroxy C 1-7 alkyl, cyano C 1-7 alkyl, amino C 1-7 alkyl, oxo C 1-7 alkyl, C 1-7 alkoxy C 1-7 alkyl, C 1-7 alkylamino, hydroxy C 1-7 alkylamino, C 1-7 alkoxy C 1-7 alkylamino, C 1-7 alkylamino C 1-7 alkyl, hydroxy C 1-7 alkylamino C 1-7 alkyl, hydroxyimino C 1-7 alkyl, C 1-7 alkoxycarbamoyl C 1-7 alkyl, —C(O)R 11 , —OC(O)R 17 , —NH—C(O)R 18 —NH—SO 2 —R 19 or an optionally substituted 5-12 membered carbocyclic or heterocyclic ring, each group linked to B-ring via a bond or via a C 1-7 alkylene linker;

R 10 is hydrogen, halogen, C 1-7 alkyl, C 2-7 alkenyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl C 1-7 alkyl, oxo, hydroxy C 1-7 alkyl, oxo C 1-7 alkyl or an optionally substituted 5 or 6 membered carbocyclic or heterocyclic ring;

R 11 is hydrogen, hydroxy, C 1-7 alkyl, hydroxy C 1-7 alkyl, C 2-7 alkenyl, C 3-7 cycloalkyl, halo C 1-7 alkyl, C 1-7 alkoxy, NR 12 R 13 , or an optionally substituted 5-12 membered carbocyclic or heterocyclic ring;

R 12 is hydrogen, C 1-7 alkyl, C 2-7 alkenyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl C 1-7 alkyl, C 1-7 alkoxy, hydroxy C 1-7 alkyl, amino C 1-7 alkyl or C 1-7 alkyl amino C 1-7 alkyl;

R 13 is hydrogen or C 1-7 alkyl;

R 14 and R 15 are, independently, hydrogen or C 1-7 alkyl;

R 14 ′ and R 15 ′ are, independently, hydrogen or C 1-7 alkyl, or R 14 ′ and R 15 ′ together form a bond;

R 17 is C 1-7 alkyl, C 2-7 alkenyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl C 1-7 alkyl, C 1-7 alkoxy, amino C 1-7 alkyl, C 1-7 alkylamino or C 1-7 alkylamino C 1-7 alkyl;

R 18 is C 1-7 alkyl, C 2-7 alkenyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl C 1-7 alkyl, amino C 1-7 alkyl, C 1-7 alkylamino or C 1-7 alkylamino C 1-7 alkyl;

R 19 is C 1-7 alkyl, C 2-7 alkenyl, C 3-7 cycloalkyl or C 3-7 cycloalkyl C 1-7 alkyl;

R 20 is hydrogen, C 1-7 alkyl, C 2-7 alkenyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl C 1-7 alkyl or C 1-7 alkoxy;

R 21 is cyano C 1-7 alkyl or, in case R x is CF 3 , R 21 can also be hydroxy C 1-7 alkyl;

R 22 is hydroxy C 1-7 alkyl;

R 23 is C 1-7 alkyl or hydroxy C 1-7 alkyl;

R 24 is hydroxy, halogen or C 1 —, alkoxy;

ring B is chosen from any one of the following groups and tautomers thereof

or pharmaceutically acceptable salts thereof;

with the proviso that the compound of formula (II) is not any of the following compounds:

(S)-3-acetyl-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-5-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-(pyridin-4-yl)-1H-pyrazole-3-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-(2-fluoroethyl)-2-methyl-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3-(1H-imidazol-4-yl)-1,2,4-oxadiazole-5-carboxamide;

(S)-5-acetyl-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)isoxazole-3-carboxamide;

N—((S)-1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(1-hydroxyethyl)isoxazole-3-carboxamide;

(S)-5-acetyl-N-(2-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propyl)isoxazole-3-carboxamide;

(S)—N-(2-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propyl)-2-methyl-1H-imidazole-4-carboxamide;

N—((S)-1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3-(1-hydroxyethyl)-1H-pyrazole-5-carboxamide;

(R)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-methyl-1H-imidazole-4-carboxamide;

(S)—N-{1-[3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl]propan-2-yl}-2-methyl-1H-imidazole-4-carboxamide;

(S)—N-{1-[3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl]propan-2-yl}-1-methyl-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3H-imidazo[4,5-b]pyridine-5-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(pyridin-3-yl)thiazole-4-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-(pyridin-3-yl)-1H-pyrazole-3-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-methyl-1-(3-oxobutyl)-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-(3-hydroxy-3-methylbutyl)-2-methyl-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)imidazo[1,2-a]pyridine-2-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-(pyridin-3-yl)-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(2-hydroxypropan-2-yl)oxazole-4-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)imidazo[1,2-a]pyrimidine-2-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3-fluoroimidazo[1,2-a]pyridine-2-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-4,5,6,7-tetrahydro-2H-indazole-3-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-(6-methylpyridin-2-yl)-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-6,7-dihydro-4H-pyrano[3,4-d]isoxazole-3-carboxamide; or

(S)—N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(2-hydroxypropan-2-yl)isoxazole-3-carboxamide.

2. The compound according to claim 1 , wherein the compound is of formula (I), wherein R x is halogen; R 14 is C 1-7 alkyl; and ring A is chosen from groups (1), (2), (3), (5), (6), (7) and (8).

3. The compound according to claim 2 , wherein R x is chloro, R 14 is methyl, and ring A is any of groups (1), (2), (5), (6) or (7), R 1 is hydroxy C 3-7 alkyl, imidazolyl or carboxy C 1-7 alkyl carbonyloxy C 1-7 alkyl; R 2 is C 1-7 alkyl, C 2-7 alkenyl or methylpyrazolyl; R 5 is C 1-7 alkyl, C 3-7 cycloalkyl, hydroxy C 1-7 alkyl or methylpyrazolyl; R 6 is C 1-7 alkyl, cyano C 1-7 alkyl or hydroxy C 1-7 alkyl; and R 8 is C 1-7 alkyl, halogen, oxo C 1-7 alkyl or hydroxy C 1-7 alkyl.

4. The compound according to claim 1 , wherein the compound is of formula (II) wherein R 14 is C 1-7 alkyl; R 14 ′, R 15 and R 15 ′ is hydrogen; ring B is chosen from groups (1′), (2′), (3′), (4′), (8′), (16′), (17′), (21′), (23′), (24′), (25′), (26′), (29′), (39′), (40′), (42′) and (43′); R 9 is hydrogen, halogen, cyano, oxo, C 1-7 alkyl, C 2-7 alkenyl, C 3-7 cycloalkyl, halo C 1-7 alkyl, cyano C 1-7 alkyl, hydroxy C 1-7 alkyl, oxo C 1-7 alkyl, —NH—SO 2 —R 19 or an optionally substituted 5-12 membered heterocyclic ring, wherein each R 9 group is linked to B-ring via a bond or via a C 1-7 alkylene linker; R 10 is hydrogen, C 1-7 alkyl or C 3-7 cycloalkyl; and R 19 is C 1-7 alkyl.

5. The compound according to claim 4 , wherein the 5-12 membered heterocyclic ring is pyrazole, pyridine, isoxazole or imidazole ring, wherein the 5-12 membered heterocyclic ring is attached to B-ring via a bond or via C 1-7 alkylene linker.

6. The compound according to claim 5 , wherein the 5-12 membered heterocyclic ring contains comprises 1-3 substituents chosen from C 1-7 alkyl, C 3-7 cycloalkyl, halogen and hydroxy C 1-7 alkyl.

7. The compound according to claim 4 , wherein R z is hydrogen or fluoro, R 14 is methyl; R 14 ′, R 15 and R 15 ′ is hydrogen; ring B is any of groups (1′), (2′), (4′), (17′), (21′) or (25′); R 9 is hydrogen, halogen, cyano, oxo, C 1-7 alkyl, C 2-7 alkenyl, C 3-7 cycloalkyl, halo C 1-7 alkyl, hydroxy C 1-3 alkyl, cyano C 1-7 alkyl, pyrazolyl, N-methylpyrazolyl, pyridinyl, isoxazolyl, imidazolyl or imidazolyl methyl; and R 10 is hydrogen, C 1-7 alkyl or C 3-7 cycloalkyl.

8. The compound according to claim 1 , wherein the compound is

(S)—N-(1-(3-(3-Chloro-4-cyano-2,5-difluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-methyl-1H-imidazole-5-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-2,5-difluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-2-(2-hydroxypropan-2-yl)oxazole-5-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-6-cyanoimidazo[1,2-a]pyridine-2-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-7-oxo-5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine-2-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3-isopropyl-1,2,4-oxadiazole-5-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5,7-dimethylimidazo[1,2-c]pyrimidine-2-carboxamide;

(S)-5-((1H-Imidazol-1-yl)methyl)-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)isoxazole-3-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-oxo-5,6-dihydroimidazo[1,2-c]pyrimidine-2-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1,6-dihydropyrrolo[2,3-c]pyrazole-5-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)imidazo[2,1-b]thiazole-6-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-6-nitroimidazo[1,2-a]pyridine-2-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-1-isopropyl-2-methyl-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(2-hydroxypropan-2-yl)-1H-pyrazole-3-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-1-(2,2-difluoroethyl)-2-methyl-1H-imidazole-4-carboxamide;

N—((S)-1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-1-((R)-2-hydroxypropyl)-2-methyl-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1′-methyl-1′1H-1,4′-bipyrazole-3-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H,2′H-3,3′-bipyrazole-5-carboxamide;

N—((S)-1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-1-((S)-2-hydroxypropyl)-2-methyl-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3,3′-bipyridine-6-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-6-(3,3-dimethylureido)imidazo[1,2-a]pyridine-2-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-6-(methylsulfonamido)imidazo[1,2-a]pyridine-2-carboxamide;

N—((S)-1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(1-hydroxy-2-methylpropyl)isoxazole-3-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(1,5-dimethyl-1H-pyrazol-3-yl)-1,2,4-oxadiazole-3-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(isoxazol-3-yl)-1,2,4-oxadiazole-3-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-3-(1H-imidazol-4-yl)-1H-pyrazole-5-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(chloropropan-2-yl)oxazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-2-(2-propen-2-yl)oxazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-N-5-cyclopropylisoxazole-3,5-dicarboxamide;

(S)-2-Bromo-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-(2-methylprop-1-enyl)-1H-pyrazole-3-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-cyclopropyl-1H-pyrazole-3-carboxamide;

N—((S)-1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(1-hydroxyethyl)-1H-imidazole-4-carboxamide;

(S)-2-acetyl-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(2-hydroxypropan-2-yl)-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-2-cyclopropyl-1-methyl-1H-imidazole-4-carboxamide;

(S)—N 4 -(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-imidazole-2,4-dicarboxamide:

4-(1-(3-((S)-1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl-carbamoyl)-1H-pyrazol-5-yl)ethoxy)-4-oxobutanoic acid;

(S)-5-Chloro-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-pyrazine-2-carboxamide;

N—((S)-1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-((S)-2-hydroxypropyl)-2-methyl-1H-imidazole-4-carboxamide;

(S)-1-Butyl-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-methyl-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(2-hydroxypropan-2-yl)-1H-pyrazole-3-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1′-methyl-1′1H-1,4′-bipyrazole-3-carboxamide;

N—((S)-1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-((R)-2-hydroxypropyl)-2-methyl-1H-imidazole-4-carboxamide;

(S)-2-Bromo-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-1H-imidazole-4-carboxamide;

N—((S)-1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(1-hydroxy-2-methylpropyl)isoxazole-3-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-(2-cyanoethyl)-2-methyl-1H-imidazole-4-carboxamide;

N—((S)-1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-(1-cyanoethyl)-2-methyl-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-(2-methylprop-1-enyl)-1H-pyrazole-3-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3-(1H-imidazol-4-yl)-1H-pyrazole-5-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-cyclopropyl-1H-pyrazole-3-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-(6-(dimethylamino)pyridin-3-yl)-1H-pyrazole-3-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxamide);

N—((S)-1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(1-hydroxyethyl)-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-isopropyl-1H-imidazole-4-carboxamide;

(S)-2-Butyl-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-methyl-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(2-hydroxypropan-2-yl)-1-methyl-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-cyclopropyl-1-methyl-1H-imidazole-4-carboxamide;

(S)—N 4 -(1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-imidazole-2,4-dicarboxamide;

(S)—N-(1-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(2-hydroxypropan-2-yl)oxazole-4-carboxamide or a pharmaceutically acceptable salt thereof.

9. The compound according to claim 1 , wherein the compound is

(S)—N-(2-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propyl)-2-(2-hydroxypropan-2-yl)oxazole-4-carboxamide;

(R)—N-(2-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propyl)-2-(2-hydroxypropan-2-yl)oxazole-4-carboxamide;

(R)—N-(2-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propyl)-2-(2-hydroxypropan-2-yl)-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(2,2,2-trifluoroethyl)-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(trifluoromethyl)-1H-imidazole-4-carboxamide;

N—((S)-1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3-((S)-1-hydroxyethyl)-1,2,4-oxadiazole-5-carboxamide;

N—((S)-1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3-((R)-1-hydroxyethyl)-1,2,4-oxadiazole-5-carboxamide;

(S)—N-(2-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propyl)-3-(2-hydroxypropan-2-yl)-1,2,4-oxadiazole-5-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-3-(2-hydroxypropan-2-yl)-1,2,4-oxadiazole-5-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-cyclopropyl-1H-imidazole-4-carboxamide;

(S)—N 4 -(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-N 2 ,N 2 -dimethyl-1H-imidazole-2,4-dicarboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(2-ethoxypropan-2-yl)-1H-imidazole-4-carboxamide;

N—((S)-1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(1-ethoxyethyl)-1H-imidazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-2-(2-ethoxypropan-2-yl)oxazole-4-carboxamide;

(S)—N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(2-hydroxy-2-methyl propyl)-1H-pyrazole-3-carboxamide;

or a pharmaceutically acceptable salt thereof.

10. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.

11. A method for the treatment of an androgen receptor dependent cancer, comprising administering to a subject in need thereof a therapeutically effective amount of a compound according to claim 1 .

12. The method according to claim 11 , wherein the androgen receptor dependent cancer is prostate cancer.