Medical food for cognitive decline
Nutraceutical formulations that improve cognitive function in adults diagnosed with neurodegenerative disease are provided, which comprise a combination of fisetin and DHA.
1. A composition comprising a synergistic combined amount of fisetin and docosahexaenoic acid (DHA) in a ratio effective in reducing cognitive defects.
2. The composition of claim 1 , wherein the ratio of fisetin to DHA by weight is from about 1:20 to 20:1.
3. The composition of claim 2 , wherein the ratio of fisetin to DHA by weight is from about 1:1 to 1:20.
4. The composition of claim 3 , wherein the ratio of fisetin to DHA by weight is from about 1:5 to 1:20.
5. The composition of claim 4 , wherein the composition comprises at least 500 mg DHA.
6. A unit dose composition comprising a synergistic combined amount of fisetin and docosahexaenoic acid (DHA) effective in reducing cognitive defects, in a dose comprising at least about 1 g. DHA; and wherein the ratio of DHA to fisetin by weight is from about 1:2 to 1:10.
7. The composition of claim 6 , wherein the composition comprises at least about 5 g. DHA.
8. The composition of claim 1 , wherein the composition consists essentially of fisetin and DHA.
9. The composition of claim 1 , wherein the composition is a dietary supplement.
10. The composition of claim 1 , wherein the composition is formulated for administration to a subject.
11. The composition of claim 1 , wherein the composition is formulated for use as a food additive.
12. The composition of claim 1 , wherein the composition is formulated as a liquid.
13. A method of improving cognitive performance in a subject, the method comprising administering a composition according to claim 6 .
14. The method of claim 13 , wherein the subject suffers from a neurodegenerative disorder.
15. The method of claim 14 , wherein the neurodegenerative disorder is Alzheimer's disease.
16. The method of claim 13 , wherein the formulation is administered orally.