IP Library Granted Patent US 9,581,668
Granted Patent B2
US 9,581,668 · App. 14/125,418 · Granted Feb 28, 2017

Multiple resonance NMR spectroscopy using a single transmitter

Inventor: Kevin W. Waddell (Hendersonville, TN)
Assignee: Vanderbilt University
G01R33/543G01R33/3635G01R33/46
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Quick Facts
Patent No.
US 9,581,668
App. No.
14/125,418
Granted
Feb 28, 2017
Kind
B2
Abstract

An NMR imaging system comprising a transceiver module configured to couple with a magnetic resonance transmitter coil, where the transceiver module includes a first transmitter channel and a pulse programmer configured to control the transceiver module, the transceiver module generating a precession and nutation for observing rotation at multiple intervals about the carrier (“PANORAMIC”) waveform, the PANORAMIC waveform configured to produce nuclear polarization. The PANORAMIC waveform may a single-banded PANORAMIC waveform or a multiple-banded PANORAMIC waveform. A method of NMR spectroscopy or imaging, the method comprising: determining for a nuclear spin rotation at least one frequency interval and at least one corresponding phase; creating a PANORAMIC waveform for the at least one frequency interval and the at least one corresponding phase; and applying the PANORAMIC waveform from an amplifier output to a probe input. The PANORAMIC waveform may be a single-banded PANORAMIC waveform or a multiple-banded PANORAMIC waveform.

Claims (29)

1. An NMR imaging system comprising:

a transceiver module configured to couple with a magnetic resonance transmitter coil, wherein the transceiver module includes a first transmitter channel; and

a pulse programmer configured to control the transceiver module, the transceiver module generating a PANORAMIC waveform, the PANORAMIC waveform configured to produce nuclear polarization;

wherein the magnetic resonance transmitter coil is a double-tuned proton/carbon-13 coil.

2. The NMR imaging system of claim 1 , wherein the transmitter channel is a phase and amplitude-modulated transmitter channel.

3. The NMR imaging system of claim 1 , wherein the PANORAMIC waveform is a single-banded PANORAMIC waveform.

4. The NMR imaging system of claim 1 , wherein the PANORAMIC waveform is a multiple-banded PANORAMIC waveform.

5. The NMR imaging system of claim 1 , wherein the PANORAMIC waveform is applied from a single amplifier output to a single probe input.

6. The NMR imaging system of claim 1 , wherein the magnetic resonance transmitter coil is configured to accept multiple frequency inputs and produce more than two resonant responses and wherein the PANORAMIC waveform multiplexes at least one of the resonant responses.

7. The NMR imaging system of claim 1 , wherein the transceiver module further includes a second transmitter channel.

8. A method of NMR spectroscopy or imaging, the method comprising:

determining for a nuclear spin rotation at least one frequency interval and at least one corresponding phase;

creating a PANORAMIC waveform for the at least one frequency interval and the at least one corresponding phase; and

applying the PANORAMIC waveform from an amplifier output to a probe input and

interleaving the PANORAMIC waveforms.

9. The method of claim 8 , wherein the PANORAMIC waveform is a single-banded PANORAMIC waveform.

10. The method of claim 8 , wherein the PANORAMIC waveform is a multiple-banded PANORAMIC waveform.

11. The method of claim 8 , further comprising the step of making adjustments to inter-pulse spacings to match the frequency bands to multinuclear frequencies.

12. The method of claim 8 , further comprising the step of scaling the amplitudes of the PANORAMIC waveforms.

13. The method of claim 8 , wherein the NMR spectroscopy or imaging takes place using a static magnetic field of 10 mT to 15 mT.

14. A method of NMR spectroscopy or imaging, the method comprising:

determining for a nuclear spin rotation at least one frequency interval and at least one corresponding phase;

creating a PANORAMIC waveform for the at least one frequency interval and the at least one corresponding phase; and

applying the PANORAMIC waveform from an amplifier output to a probe input;

wherein the NMR spectroscopy or imaging takes place using a static magnetic field of 10 mT to 15 mT.

15. The method of claim 14 , wherein the PANORAMIC waveform is a single-banded PANORAMIC waveform.

16. The method of claim 14 , wherein the PANORAMIC waveform is a multiple-banded PANORAMIC waveform.

17. The method of claim 14 , further comprising the step of making adjustments to inter-pulse spacings to match the frequency bands to multinuclear frequencies.

18. The method of claim 14 , further comprising the step of scaling the amplitudes of the PANORAMIC waveforms.

Assignments (2)
CONFIRMATORY LICENSE Recorded Dec 2, 2016
From: VANDERBILT UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 040492/0665 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 11, 2013
From: WADDELL, KEVIN W.
To: VANDERBILT UNIVERSITY
Reel/Frame 031759/0480 →
Continuity (2)
Provisional Application 61496552 · Jun 13, 2011
Related Publication 20140132265A1 · May 15, 2014