Film-forming composition, and use thereof for treating herpes
The present invention relates to a topical film-forming composition including, in a pharmaceutically acceptable medium: 5 to 30 wt % of ethyl cellulose; 0.1 to 10 wt % of an auxiliary film-forming agent; 0.1 to 20 wt % of one or more triacids, at least one of which is boric acid; and 60 to 95 wt % of an organic solvent, the percentages being expressed by weight relative to the total weight of the composition. The invention also relates to the use of such a composition in a method for treating herpes, in particular herpes labialis.
1. A topical film-forming composition comprising, in a pharmaceutically acceptable medium:
5% to 30% by weight of ethylcellulose;
0.1% to 20% by weight of an auxiliary film-forming agent;
0.1% to 5% by weight of one or more triacids, at least one of which is boric acid; and
60% to 95% by weight of an organic solvent,
the percentages being expressed by weight, relative to the total weight of the composition.
2. The composition of claim 1 , wherein the ethylcellulose is present in a content ranging from 8% to 20% by weight relative to the total weight of the composition.
3. The composition of claim 2 , wherein the ethylcellulose is present in a content ranging from 8% to 15% by weight, relative to the total weight of the composition.
4. The composition of claim 1 , wherein the auxiliary film-forming agent is chosen from oxyethylenated derivatives.
5. The composition of claim 4 , wherein the oxyethylenated derivative is an oxyethylenated oil.
6. The composition of claim 5 , wherein said oxyethylenated oil is vegetable oil.
7. The composition of claim 1 , wherein the auxiliary film-forming agent is present in a content ranging from 2% to 12% by weight, relative to the total weight of the composition.
8. The composition as of claim 1 , wherein the triacid comprises a mixture of boric acid and citric acid.
9. The composition of claim 8 wherein the mixture of boric acid and citric acid is in a weight ratio of between 1:2 and 2:1.
10. The composition of claim 1 , wherein the organic solvent is chosen from alcohols which are liquid at ambient temperature.
11. The composition of claim 10 , wherein the alcohol is selected from the group consisting of ethanol, isopropanol, diacetone alcohol, 2 butoxyethanol, cyclohexanol, and mixtures thereof.
12. The composition of claim 11 , wherein the alcohol is ethanol.
13. The composition as of claim 1 , wherein the organic solvent represents 65% to 85% by weight, relative to the total weight of the composition.
14. The composition of claim 1 , wherein said composition further comprises water.
15. The composition of claim 14 , wherein said water content is present ranging from 1% to 20% by weight of said composition.
16. The composition of claim 15 wherein said water content is present ranging from 5% to 15% by weight of said composition.
17. The composition of claim 1 , wherein it does not contain any additional pharmaceutically active agent for the treatment of herpes.
18. A method for treating herpes, comprising the application of a composition as of claim 1 .
19. A method according to claim 18 wherein treating herpes is herpes labialis.