Granulated material mixture comprising two different granulated materials for artificial callus distraction
A granulate mixture suitable for regenerating a bone contains at least one expandable particle and at least one nondeformable particle. The at least one expandable particle contains a swelling agent. The swelling is enclosed by a biodegradable sheathing or be a biodegradable casing. Three-dimensional callus distraction may be accomplished by introducing the granulated mixture into a bone defect.
1. A granulate mixture suitable for regenerating a bone comprising a plurality of nondeformable particles and a plurality of expandable particles;
wherein the nondeformable particles of the plurality of nondeformable particles have a particle size of 0.01 mm to 10 mm.
2. The granulate mixture according to claim 1 , wherein a mixing ratio of the plurality of expandable particles to the plurality of nondeformable particles in the granulate mixture is 1:99 to 99:1, relative to a number of particles.
3. The granulate mixture according to claim 1 , wherein the plurality of expandable particles is composed of a swelling agent.
4. The granulate mixture according to claim 3 , wherein the swelling agent is a hydrogel.
5. The granulate mixture according to claim 3 , wherein the swelling agent expands as a result of absorption of a liquid selected from a group consisting of: a liquid containing biomolecules, cells, and a combination thereof.
6. The granulate mixture according to claim 5 , wherein the liquid is blood.
7. The granulate mixture according to claim 3 , wherein the swelling agent for the plurality of expandable particles is composed of a polysaccharide.
8. The granulate mixture according to claim 3 , wherein the swelling agent for the plurality of expandable particles is composed of a glucosamine.
9. The granulate mixture according to claim 1 , wherein the expandable particles of the plurality of expandable particles have a particle size of 0.0001 mm to 10 mm.
10. The granulate mixture according to claim 1 , wherein the expandable particles of the plurality of expandable particles have a particle size of 0.1 mm to 10 mm.
11. The granulate mixture according to claim 1 , wherein the expandable particles of the plurality of expandable particles are present in at least two different particle sizes.
12. The granulate mixture according to claim 1 , wherein the plurality of nondeformable particles contains a bone replacement material.
13. The granulate mixture according to claim 1 , wherein the plurality of nondeformable particles contains hydroxyapatite and/or tricalcium phosphate.
14. The granulate mixture according to claim 1 , wherein the nondeformable particles of the plurality of nondeformable particles have a particle size of 0.1 mm to 10 mm.
15. A granulate mixture suitable for regenerating a bone comprising:
a plurality of nondeformable particles; and
a plurality of expandable particles having a swelling agent, wherein the swelling agent expands as a result of absorption of a liquid selected from a group consisting of: a liquid containing biomolecules, cells, and a combination thereof;
wherein a mixing ratio of the plurality of expandable particles to the plurality of nondeformable particles in the granulate mixture is 1:99 to 99:1, relative to a number of particles;
wherein the expandable particles of the plurality of expandable particles have a article size of 0.0001 mm to 10 mm, and further wherein the nondeformable particles of the plurality of nondeformable particles have a particle size of 0.01 to 10 mm.
16. The granulate mixture according to claim 15 , wherein the swelling agent is selected from a group consisting of a polysaccharide and a glucosamine.
17. The granulate mixture according to claim 15 , wherein the plurality of nondeformable particles contains hydroxyapatite and/or tricalcium phosphate.
18. The granulate mixture according to claim 15 , wherein the plurality of nondeformable particles contains a bone replacement material.
19. The granulate mixture according to claim 15 , wherein the expandable particles of the plurality of expandable particles are present in at least two different particle sizes.