Lipid-lowering antidiabetic agent
A composition which includes a salt of metformin and the use of the composition for treatment of or use in prediabetes, diabetes, lowering triglycerides and/or other conditions in mammals.
1. A pharmaceutical composition comprising a metformin salt of docosahexaenoic acid or a mixture of eicosapentaenoic acid and docosahexaenoic acid, the composition having an aqueous solubility of at least 50 mg/ml under standard conditions.
2. The pharmaceutical composition of claim 1 , wherein the composition is prepared by a process comprising the following steps
adding dropwise at room temperature to a concentrated solution of metformin free base in acetonitrile docosahexaenoic acid, or a mixture of eicosapentaenoic acid and docosahexaenoic acid,
stirring the reaction mixture for one hour at room temperature in a container protected from light,
chilling the reaction mixture to 0 C. for one hour,
filtering the chilled reaction mixture under an atmosphere of nitrogen, and
drying the mixture to a powder.
3. A pharmaceutical composition comprising a metformin salt of docosahexaenoic acid or a mixture of eicosapentaenoic acid and docosahexaenoic acid.