CHEMICAL ENTITIES AND THERAPEUTIC USES THEREOF

1 . A compound of Formula I

and pharmaceutically acceptable salts thereof, wherein

W 1 is CR 6 , CHR 6 , NR 6 , or N;

W 2 is CR 7 , N, or NR 7 ;

W 3 is CR 2 , CHR 2 , N, or NR 2 ;

W 4 is CR 11 or N;

W 5 is C(O), CHR 3 , or CR 3 ; and no more than two adjacent ring atoms are N or NR 7 ;

R 1 is hydrogen, amino, alkyl, alkoxy, aryl, heteroaryl, or cyano;

R 2 is hydrogen, halo, amino, alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl or X;

R 3 is hydrogen, amino, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or X;

R 4 is hydrogen and R 5 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, amino, alkoxycarbonyl, or acyl; or R 4 and R 5 , taken together with any intervening atoms, form a heteroaryl ring;

R 6 is hydrogen, halo, amino, alkoxy, lower alkyl, cyano, or X when W 1 is CR 6 or CHR 6 ; or R 6 is hydrogen or lower alkyl when W 1 is NR 6 ;

R 7 is hydrogen, halo, lower alkyl, or aryl when W 2 is CR 7 ; or R 7 is hydrogen, lower alkyl, or aryl when W 2 is NR 7 ; or R 7 and R 3 , taken together with any intervening atoms, form a cycloalkyl, heterocycloalkyl, or heteroaryl ring;

R 8 and R 9 are independently hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, or R 8 and R 9 taken together with any intervening atoms, form a heterocycloalkyl ring;

R 10 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;

R 11 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or X; or R 11 and R 5 taken together with any intervening atoms, form a heterocycloalkyl or heteroaryl ring; and

X is —C(O)NR 8 R 9 , —SO 2 NR 8 R 9 , —NHC(O)NR 8 R 9 , or —NR 8 C(O)R 10 .

2 .- 59 . (canceled)