IP Library › Granted Patent US 9,555,100
Granted Patent B2
US 9,555,100 · App. 14/141,251 · Granted Jan 31, 2017

Herpes virus vaccine and methods of use

Inventors: Deborah H. Spector (La Jolla, CA); Christopher S. Morello (Carlsbad, CA); Kimberly A. Kraynyak (Encinitas, CA)
Assignee: The Regents of the University of California
A61K39/245A61K39/12A61K33/06A61K2039/5252A61K2039/53A61K2039/54A61K2039/545A61K2039/55505A61K2039/55572C12N2710/16634
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Quick Facts
Patent No.
US 9,555,100
App. No.
14/141,251
Granted
Jan 31, 2017
Kind
B2
Abstract

Provided herein are, for example, immunogenic compositions and methods of using the same for the treatment or prevention of Herpesvirus infections.

Claims (10)

1. A kit consisting of one or more immunogenic compositions and instructions for use, wherein each of said one or more immunogenic compositions comprise:

i) an inactivated human herpesvirus (HV);

ii) monophosphoryl lipid A (MPL); and

iii) an aluminum hydroxide adjuvant or aluminum phosphate adjuvant;

wherein

each of said one or more immunogenic compositions is provided in unit dosage form within a container and does not comprise DNA that is immunogenic; and wherein said inactivated human herpesvirus comprises inactivated genomic DNA that is not immunogenic.

2. The kit of claim 1 , wherein said inactivated human herpesvirus is a Herpes Simplex Virus (HSV).

3. The kit of claim 2 , wherein said inactivated human herpesvirus is formed by chemical inactivation.

4. The kit of claim 2 , wherein said inactivated human herpesvirus is formed by contacting said inactivated human herpesvirus with one or more agents selected from a cross-linking agent, oxidizing agent, reducing agent, heat, radiation, detergent, a pH changing agent, furocoumarin, aziridine, ethylenimine, binary ethylenimine, and beta-propiolactone.

5. The kit of claim 1 , wherein said herpesvirus is a Herpes Simplex Virus 2.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 27, 2016
From: SPECTOR, DEBORAH H.; MORELLO, CHRISTOPHER S.; KRAYNYAK, KIMBERLY A.
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 038737/0214 →
CONFIRMATORY LICENSE Recorded Feb 19, 2014
From: UNIVERSITY OF CALIFORNIA SAN DIEGO
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 032284/0832 →
Continuity (3)
Continuation PCTUS2012045290 · Jul 2, 2012
Provisional Application 61503945 · Jul 1, 2011
Related Publication 20140193460A1 · Jul 10, 2014