Nucleoside phosphoramidates
Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.
1. A diastereoselective process for preparing (Sp-4):
comprising:
i) reacting compound C:
wherein LG′ is p-nitrophenoxide, 2,4-dinitrophenoxide or pentafluorophenoxide with a basic reagent and compound 3:
wherein Z is hydrogen, to obtain Sp-4; or
ii) reacting compound C with a basic reagent and compound 3, wherein Z is a protecting group, and deprotecting to obtain S P -4.
2. The process of claim 1 , wherein Z is hydrogen.
3. The process of claim 1 , wherein no chromatography is performed.
4. The process of claim 1 , wherein LG′ is p-nitrophenoxide.
5. The process of claim 1 , wherein LG′ is pentafluorophenoxide.