Corneal implant systems and methods

1. A method of making an implant for correcting vision impairment, comprising:

receiving a donor corneal tissue, the donor corneal tissue including stromal tissue between an anterior surface and a posterior surface;

cutting a plurality of lamellar sheets from the stromal tissue, wherein cuts are made between the posterior surface and the anterior surface and parallel to the posterior surface or the anterior surface to define surfaces of the lamellar sheets, and the lamellar sheets are defined by lamellar layers in the stromal tissue, parallel to the posterior surface or the anterior surface;

cutting a plurality of lenticules from the lamellar sheets; and

selecting at least one of the lenticules to be reshaped to form an implant having a shape and size configured for a predetermined refractive correction.

2. The method of claim 1 , further comprising reshaping the at least one of the lenticules to form an implant having a shape and size configured for a predetermined refractive correction.

3. The method of claim 2 , wherein the at least one of the lenticules is reshaped prior to the lenticule being cut from the lamellar sheets.

4. The method of claim 2 , wherein the reshaping includes reshaping a surface of the at least one of the lenticules to have a profile based on a surface profile of an implantation site of a cornea.

5. The method of claim 1 , wherein the lamellar sheets are cut from the stromal tissue by a femtosecond laser.

6. The method of claim 2 , wherein the at least one of the lenticules is reshaped to form the implant using an excimer laser.

7. The method of claim 1 , wherein the cutting the lamellar sheets from the stromal tissue is performed in a controlled environment that maintains the implant at a state of hydration that generally corresponds to a state of hydration of a recipient cornea.

8. The method of claim 1 , wherein selecting at least one of the lenticules includes selecting a plurality of the lenticules to be reshaped to form a plurality of implants, wherein the plurality of implants are configured to provide a plurality of different refractive corrections.

9. The method of claim 1 , further comprising:

engaging the donor corneal tissue with a first engagement device, the lamellar sheets being cut from the stromal tissue while the donor corneal tissue engages the first engagement device; and

after the cutting of each lamellar sheet from the stromal tissue, transferring the lamellar sheet from the first engagement device to a second engagement device, one or more of the lenticules being cut from the lamellar sheet while the lamellar sheet is engaged by the second engagement device.

10. The method of claim 9 , wherein the first engagement device includes a first engagement surface for engaging the donor corneal tissue, the first engagement surface includes a cavity and the first engagement device is configured to apply a vacuum pressure to the donor corneal tissue to capture a portion of the donor corneal tissue within the cavity while the lamellar sheets are cut from the stromal tissue.

11. The method of claim 10 , wherein the vacuum pressure is applied to the donor corneal tissue via a fluid in contact with the donor corneal tissue.

12. The method of claim 9 , further comprising applanating the donor corneal tissue using the first engagement device while the lamellar sheets are cut from the stromal tissue.

13. The method of claim 2 , further comprising determining the topography of a cornea, the plurality of lenticules being cut from the lamellar sheets and the at least one of the lenticules being reshaped to form the implant based on the determined topography of the cornea.

14. The method of claim 1 , further comprising applying a cross-linking agent to the donor corneal tissue and activating the cross-linking agent to strengthen the donor corneal tissue.

15. The method of claim 1 , further comprising sterilizing the implant.