IP Library › Granted Patent US 10,041,124
Granted Patent B2
US 10,041,124 · App. 14/153,651 · Granted Aug 7, 2018

Methylation biomarkers for ovarian cancer

Inventors: Hicham Mansour (Thuwal, SA); Roberto Incitti (Thuwal, SA); Vladimir Bajic (Thuwal, SA)
Assignee: King Abdullah University of Science and Technology
C12Q1/6886C12Q2600/154
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Quick Facts
Patent No.
US 10,041,124
App. No.
14/153,651
Granted
Aug 7, 2018
Kind
B2
Abstract

Different combinations of methylation status based biomarkers can be used to test for ovarian cancer with high sensitivity and high specificity.

Claims (3)

1. A method comprising:

measuring, in a DNA sample from ovarian stroma, ovarian surface epithelial cells, or both, a methylation level in a CpG promoter island of each gene in a set of genes, wherein the set of genes consists of CYP39A1, DAPK1, CAV1, ARMCX1, ROCK1, MED1, SFRP1, and CCND2, and optionally any one or more of CDKN1B, MLH1, MED1, PEGS, BEX4, SPARC11, ARMCX2, PLAGL1, RAD51C, SOCS2, RARRES1, UCHL1 and DIRAS.

2. The method of claim 1 , wherein the methylation level is determined by methylation-specific PCR.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 15, 2016
From: MANSOUR, HICHAM; INCITTI, ROBERTO; BAJIC, VLADIMIR
To: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY
Reel/Frame 040995/0883 →
Continuity (2)
Provisional Application 61752156 · Jan 14, 2013
Related Publication 20140199696A1 · Jul 17, 2014