Small molecule inhibitors of HIV proteases
Described herein are compounds, compositions, and methods for treating HIV and related diseases.
1. A pharmaceutical composition comprising compound of the formula:
Wherein:
R 1 is optionally substituted alkyl or aryl;
R 2 is hydrogen or optionally substituted alkyl;
R 5 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, or nitrile;
R 7 is hydrogen;
R 8 is optionally substituted arylalkyl; and
R 11 is hydrogen, alkyl, arylalkyl, or a pro-drug moiety; and one or more carriers, diluents or excipients, and combinations thereof.
2. The pharmaceutical composition of claim 1 , wherein R 1 is optionally substituted aryl.
3. The pharmaceutical composition of claim 2 , wherein the aryl is phenyl.
4. The pharmaceutical composition of claim 2 , wherein the aryl is substituted with alkyl, alkoxy, nitro, amino, or alkoxyalkyl.
5. The pharmaceutical composition of claim 1 , wherein R 8 is aryl optionally substituted with hydroxyl, alkoxy or hydroxyalkyl.
6. The pharmaceutical composition of claim 1 , wherein R 5 is arylalkyl, alkoxyalkyl, or aminoalkyl.
7. A method for treating a patient in need of relief from HIV, AIDS, or an AIDS-related disease, the method comprising the step of administering to the patient a therapeutically effective amount of the pharmaceutical composition of claim 1 .