IP Library Granted Patent US 8,945,441
Granted Patent B2
US 8,945,441 · App. 14/157,971 · Granted Feb 3, 2015

Methods and materials for fabricating laminate nanomolds and nanoparticles therefrom

Inventors: Jason P. Rolland (Belmont, MA); Benjamin Maynor (Durham, NC); Robert Lyon Henn (Raleigh, NC)
Assignee: Liquidia Technologies, Inc.
B29C33/3807B29C33/40B32B3/30B82Y10/00B82Y40/00G03F7/0002B29C43/3697B29L2031/756Y10S425/81
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Quick Facts
Patent No.
US 8,945,441
App. No.
14/157,971
Granted
Feb 3, 2015
Kind
B2
Abstract

A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.

Claims (38)

1. A method of making a laminate mold comprising:

positioning a patterned master comprising a pattern of structures adjacent to a support layer;

positioning the patterned master and adjacent support layer adjacent a nip roller;

delivering a curable polymer material selected from the group consisting of fluoropolyether, perfluoropolyether, poly(dimethyl siloxane), poly(tetramethyl oxide), poly(ethylene oxide), poly(oxetanes), polyisoprene, polybutadiene, and fluoroolefin-based fluoroelastomers between the patterned master and the support layer adjacent an input side of the nip roller;

activating the nip roller to form a laminate from the patterned master with the support layer, wherein the curable polymer material is dispersed between the patterned master and the support layer in the laminate;

treating the laminate to activate a curable component of the curable polymer material such that the curable polymer material is solidified to create a mold layer coupled to the support layer; and

separating the patterned master from the mold layer, wherein the mold layer coupled to the support layer has a modulus at least 200 times the moldulus of the mold layer alone.

2. The method of claim 1 , further comprising, before positioning the patterned master adjacent the support layer, configuring a tie-layer with the support layer such that when the curable component of the curable polymer material is activated, the curable polymer material binds with the tie-layer.

3. The method of claim 2 , wherein the tie-layer comprises a dual cure material.

4. The method of claim 1 , wherein the mold layer comprises a plurality of cavities, each cavity of the plurality of cavities corresponding to a structure of the patterned master.

5. The method of claim 4 , wherein the plurality of cavities comprises cavities having a predetermined shape.

6. The method of claim 4 , wherein each cavity of the plurality of cavities is less than about 10 micrometers in a largest dimension.

7. The method of claim 4 , wherein each cavity of the plurality of cavities is less than about 1 micrometer in a largest dimension.

8. The method of claim 1 , wherein the mold layer is less than about 50 micrometers thick.

9. The method of claim 1 , wherein the support layer comprises a polymer.

10. A method of making a laminate mold comprising:

positioning a patterned master comprising a pattern of structures adjacent to a support layer;

positioning the patterned master and adjacent support layer adjacent a nip roller;

delivering a curable polymer material selected from the group consisting of fluoropolyether, perfluoropolyether, poly(dimethyl siloxane), poly(tetramethyl oxide), poly(ethylene oxide), poly(oxetanes), polyisoprene, polybutadiene, and fluoroolefin-based fluoroelastomers between the patterned master and the support layer adjacent an input side of the nip roller;

activating the nip roller to laminate the patterned master with the support layer, wherein the curable polymer material is dispersed between the patterned master and the support layer to form a laminate;

treating the laminate to activate a curable component of the curable polymer material such that the curable polymer material is solidified to create a mold layer coupled to the support layer, the mold layer having a thickness of less than 75 micrometers; and

separating the patterned master from the mold layer, wherein the mold layer coupled to the support layer has a modulus at least 200 times the modulus of the mold layer alone.

11. The method of claim 10 , further comprising, before positioning the patterned master adjacent the support layer, configuring a tie-layer with the support layer such that when the curable component of the curable polymer material is activated, the curable polymer material binds with the tie-layer.

12. The method of claim 10 , wherein the mold layer comprises a plurality of cavities, each cavity of the plurality of cavities corresponding to a structure of the patterned master.

13. The method of claim 12 , wherein the plurality of cavities comprises cavities having a predetermined shape.

14. The method of claim 12 , wherein each cavity of the plurality of cavities is less than about 10 micrometers in a largest dimension.

15. A method of making a laminate mold comprising:

positioning a patterned master comprising a pattern of structures adjacent to a support layer;

positioning the patterned master and adjacent support layer adjacent a nip roller;

delivering a curable polymer material selected from the group consisting of fluoropolyether, perfluoropolyether, poly(dimethyl siloxane), poly(tetramethyl oxide), poly(ethylene oxide), poly(oxetanes), polyisoprene, polybutadiene, and fluoroolefin-based fluoroelastomers between the patterned master and the support layer adjacent an input side of the nip roller;

activating the nip roller to laminate the patterned master with the support layer, wherein the curable polymer material is dispersed between the patterned master and the support layer to form a laminate;

treating the laminate to activate a curable component of the curable polymer material such that the curable polymer material is solidified to create a mold layer coupled to the support layer, the mold layer comprising a plurality of cavities, each cavity of the plurality of cavities comprising a predetermined shape and a width to depth ratio of less than about 1,000:1; and

separating the patterned master from the mold layer, wherein the mold layer coupled to the support layer has a modulus at least 200 times the modulus of the mold layer alone.

16. The method of claim 15 , wherein the plurality of cavities comprise cavities of a variety of predetermined shapes.

17. The method of claim 1 , wherein the mold layer has a thickness of less than 75 micrometers.

18. The method of claim 4 , further comprising using the mold layer to form particles in the plurality of cavities of the mold layer.

19. The method of claim 12 , further comprising using the mold layer to form particles in the plurality of cavities of the mold layer.

20. The method of claim 15 , further comprising using the mold layer to form particles in the plurality of cavities of the mold layer.

Assignments (3)
ASSIGNMENT OF IP SECURITY AGREEMENT RECORDED AT REEL/FRAME 062643/0791 Recorded May 11, 2023
From: HCR COLLATERAL MANAGEMENT, LLC, AS RETIRING SUBORDINATED LENDER
To: HEALTHCARE ROYALTY PARTNERS IV, L.P., AS SUCCESSOR SUBORDINATED LENDER
Reel/Frame 063627/0307 →
SECURITY INTEREST Recorded Feb 9, 2023
From: LIQUIDIA TECHNOLOGIES, INC.
To: HCR COLLATERAL MANAGEMENT, LLC
Reel/Frame 062643/0791 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 3, 2018
From: ROLLAND, JASON P.; MAYNOR, BENJAMIN; HENN, ROBERT L.
To: LIQUIDIA TECHNOLOGIES, INC.
Reel/Frame 044520/0868 →
Continuity (4)
Division 13834454 · Mar 15, 2013
Continuation 13354046 · Jan 19, 2012
Continuation 11633763 · Dec 4, 2006
Related Publication 20140131915A1 · May 15, 2014