Compositions and methods for inducing an immune response
The present invention provides compositions and methods for inducing an immune response in a subject. In particular, the present invention provides compositions comprising immunostimulatory ligands (ISL) and methods of inducing an immune response in a subject therewith. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.
1. A composition comprising the isolated, cyclic peptide
wherein n is selected from the group consisting of 2, 4 and 6.
2. The composition of claim 1 , wherein the isolated, cyclic peptide is generated using a method selected from the group consisting of a urea backbone cyclic protocol, an amide backbone-to-side chain cyclic peptide synthesis scheme, a peptide stapling protocol, and a combination thereof.
3. An immunogenic composition comprising the isolated, cyclic peptide
wherein n is selected from the group consisting of 2, 4 and 6, and a pharmaceutically acceptable carrier.
4. The immunogenic composition of claim 3 further comprising an adjuvant.
5. The immunogenic composition of claim 3 , wherein said immunogenic composition is formulated for administration to a subject, wherein said administration is selected from the group consisting of intravenous injection, intramuscular injection, subcutaneous injection and orally.
6. The immunogenic composition of claim 3 , further comprising at least one protein from a bacterial pathogen.
7. The immunogenic composition of claim 3 , further comprising at least one tumor or cancer antigen.
8. The immunogenic composition of claim 3 , wherein the isolated, cyclic peptide is generated using a method selected from the group consisting of a urea backbone cyclic protocol, an amide backbone-to-side chain cyclic peptide synthesis scheme, a peptide stapling protocol, and a combination thereof.
9. A vaccine comprising the immunogenic composition of claim 3 .