Antibodies to TIP-1

1. An isolated antibody that binds to Tax1-binding protein 3 (TIP-1), wherein the antibody comprises a heavy chain variable domain comprising a CDR1, CDR2, and a CDR3, wherein the heavy chain variable domain CDR1 comprises SEQ ID NO:28, the heavy chain variable region CDR2 comprises SEQ ID NO:29, and the heavy chain variable region CDR3 comprises SEQ ID NO:30; and a light chain variable domain comprising a CDR1, CDR2, and a CDR3, wherein the light chain variable domain CDR1 comprises SEQ ID NO:31, the light chain variable region domain CDR2 comprises SEQ ID NO:32, and the light chain variable region domain CDR3 comprises SEQ ID NO:33.

2. The antibody of claim 1 , wherein the antibody is selected from the group consisting of a humanized antibody, a single chain variable fragment (scFv) antibody, an antigen-binding fragment, or a chimeric antibody.

3. The antibody of claim 1 , wherein the antibody comprises a heavy chain variable region comprising SEQ ID NO:25 and a light chain variable region comprising SEQ ID NO:27.

4. The antibody of claim 1 , wherein the antibody recognizes the epitope of SEQ ID NO:21.

5. The antibody of claim 1 , wherein the antibody is conjugated directly or indirectly to a payload selected from the group consisting of a therapeutic agent, an imaging agent, or a combination thereof.

6. A method of enhancing radiotherapy in a subject, the method comprising administering a pharmacologically effective amount of an antibody of claim 5 to the subject, such that radiotherapy is enhanced.

7. The method of claim 6 , further comprising administering ionizing radiation to the subject.

8. The method of claim 6 , further comprising imaging the subject.