Anti-cancer compositions and methods
Compositions and pharmaceutical compositions including one or more selenium-containing COX-2 inhibitors are provided according to aspects of the present invention. Methods of treating a subject having or suspected of having cancer are provided according to aspects of the present invention which include administering a therapeutically effective amount of a pharmaceutical composition including a selenium-containing COX-2 inhibitor.
1. A composition comprising
a selenium-containing COX-2 inhibitor, wherein the selenium-containing COX-2 inhibitor is selenocoxib-1-glutathione (selenocoxib-1-GSH).
2. A pharmaceutical composition, comprising:
a selenium-containing COX-2 inhibitor, wherein the selenium-containing COX-2 inhibitor is selenocoxib-1-GSH; and
a pharmaceutically acceptable carrier.
3. The pharmaceutical composition of claim 2 , wherein the pharmaceutical composition is formulated for topical application.
4. The pharmaceutical composition of claim 2 , wherein the pharmaceutically acceptable carrier comprises a particulate carrier.
5. The pharmaceutical composition of claim 2 , wherein the pharmaceutically acceptable carrier comprises a nanoparticulate carrier.
6. The pharmaceutical composition of claim 2 , comprising a plurality of nanoliposomes, the nanoliposomes comprising selenocoxib-1-GSH, the nanoliposomes having an average particle size in the range of 1-100 nm.
7. The pharmaceutical composition of claim 2 , further comprising an additional therapeutic agent.