IP Library › Granted Patent US 9,109,008
Granted Patent B2
US 9,109,008 · App. 14/177,498 · Granted Aug 18, 2015

Tubulysin compounds, methods of making and use

Inventors: Qiang Cong (Sunnyvale, CA); Heng Cheng (Foster City, CA); Sanjeev Gangwar (Foster City, CA)
Assignee: Bristol-Myers Squibb Company
C07K5/1024A61K38/07A61K47/48246A61K47/48415A61K47/48569A61K47/48592A61K47/48607A61K47/48615A61K47/48638C07K5/06C07K5/06139C07K5/06165C07K5/10C07K7/06C07K5/1016
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Quick Facts
Patent No.
US 9,109,008
App. No.
14/177,498
Granted
Aug 18, 2015
Kind
B2
Abstract

Tubulysin compounds of the formula (I) where R 1 , R 2 R 3a , R 3b , R 4 , R 5 , W, and n are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.

Claims (2)

1. A compound having a structure represented by formula (I-5), (I-6), or (I-7):

2. A compound according to claim 1 , having a structure represented by formula (I-7):

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 1, 2014
From: CONG, QIANG; CHENG, HENG; GANGWAR, SANJEEV
To: BRISTOL-MYERS SQUIBB COMPANY
Reel/Frame 032576/0100 →
Continuity (2)
Provisional Application 61764825 · Feb 14, 2013
Related Publication 20140227298A1 · Aug 14, 2014