Anti-Scalping Transdermal Patch Packaging Film
A flexible, multilayer packaging film suitable for packaging an article for collecting or administering a physiologically active substance such as transdermal drug delivery patches, oral dissolvable thin strips, and disposable, microfluidic test cassettes having: (a) an article contact layer having at least 90 wt. % of a norbornene ethylene copolymer or derivative thereof and a glass transition temperature of from 65 to 110° C.; (b) a polyolefin bulk layer; (c) a first intermediate adhesive layer; (d) an oxygen barrier layer having an oxygen transmission rate of less than less than 0.01 cm 3 /100 inches 2 /24 hours at 1 atmosphere and 23° C.; (e) a second intermediate adhesive layer; and (f) an exterior protective layer comprising a polymer selected from the group consisting of amorphous polyester, polyamide, polyolefin, nylon, polypropylene, or copolymers, blends or derivatives thereof; wherein said multilayer film has the following properties: a WVTR of less than 0.01 g/100 inches 2 per 24 hours at Room Temperature (RT) (23° C.) and 1 atmosphere; and a thickness of 10 mil or less.
1 . A drug scalping resistant, flexible, multilayer packaging film comprising:
(a) a drug contact layer having at least 90 wt. % of an ethylene norbornene copolymer or derivative thereof having a glass transition temperature of from 65 to 110° C.;
(b) a polyolefin bulk layer;
(c) a first intermediate adhesive layer;
(d) an oxygen barrier layer having an oxygen transmission rate of less than less than 0.01 cm 3 /100 inches 2 /24 hours at 1 atmosphere and 23° C.;
(e) a second intermediate adhesive layer; and
(f) an exterior protective layer comprising a polymer selected from the group consisting of paper, oriented polyester, amorphous polyester, polyamide, polyolefin, nylon, polypropylene, or copolymers, blends or derivatives thereof;
wherein said multilayer film has the following properties:
a WVTR of less than 0.01 g/100 inches 2 per 24 hours at Room Temperature (RT) (23° C.) and 1 atmosphere.
2 . A multilayer film as defined in claim 1 , wherein: said contact layer comprises at least 95 wt. % ethylene norbornene copolymer or derivative thereof.
3 . A multilayer film as defined in claim 1 , wherein: said contact layer consists essentially of ethylene norbornene copolymer or derivative thereof.
4 . A multilayer film as defined in claim 1 , wherein said film is formed into a flexible container and further comprises a transdermal patch sealed therein.
5 . A multilayer film as defined in claim 4 , wherein said patch is a nicotine or fentanyl drug delivery patch.