Lipids and compositions for intracellular delivery of biologically active compounds
The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.
1. A pharmaceutical composition comprising a lipid nanoparticle comprising a linear amino-lipid
2. The pharmaceutical composition of claim 1 , further comprising a biologically active compound.
3. The pharmaceutical composition of claim 2 , wherein said biologically active compound is a nucleic acid.
4. The pharmaceutical composition of claim 3 , wherein the nucleic acid is in the form of a single stranded or partially double stranded oligomer or a polymer composed of ribonucleotides.