Topical Composition for Stimulating Epidermis and Dermis Layers of the Skin
The invention provides topical compositions including vitamin A, colostrum (or extracts of colostrum with a high IGF content) with or without avian eggshell membrane, that stimulate the epidermis and dermis layers of the skin to treat skin aging.
1 . A topical composition comprising:
an effective amount of vitamin A;
an effective amount of at least one compound selected from the group consisting of: insulin like growth factors (“IGF”), colostrum, IGF extracted from colostrum, a peptide extract of colostrum which is rich IGF, and avian eggshell membrane; and
a dermatologically acceptable carrier.
2 . The topical composition of claim 1 , wherein the vitamin A comprises about 0.01% to about 0.5% by weight of the composition.
3 . The topical composition of claim 2 , wherein the vitamin A comprises about 0.05% to about 0.15% by weight of the composition.
4 . The topical composition of claim 3 , wherein the vitamin A comprises about 0.1% by weight of the composition.
5 . The topical composition of claim 1 , wherein the vitamin A is retinol.
6 . The topical composition of claim 1 , wherein the at least one compound comprises about 0.05% to about 2.0% by weight of the composition.
7 . The topical composition of claim 6 , wherein the at least one compound comprises about 0.1% to about 1.0% by weight of the composition.
8 . The topical composition of claim 7 , wherein the at least one compound comprises about 0.30% to about 0.8% by weight of the composition.
9 . The topical composition of claim 1 , wherein the dermatologically acceptable carrier comprises one or more agents selected from the group consisting of: sodium hyaluronate, phosphatidylcholine, isopropyl palmitate, cetearyl alcohol, glycerol monostearate, and dimethyl ethanolamine.
10 . The topical composition of claim 1 , wherein the pH of the composition is in the range from about 2.5 to about 6.0.
11 . The topical composition of composition of claim 10 , wherein the pH of the composition is in the range from about 3.0 to about 5.5.
12 . The topical composition of claim 11 , wherein the pH of the composition is in the range from about 3.8 to about 5.0.
13 . The topical composition of claim 1 , wherein the composition is a cream.
14 . A topical composition comprising:
about 0.01% to about 0.5% by weight vitamin A;
about 0.05% to about 2.0% by weight avian eggshell membrane or at least one component of eggshell membrane; and
a dermatologically acceptable carrier.
15 . The topical composition of claim 14 further comprising about 0.05% to about 2.0% by weight of colostrum or extracts of colostrum rich in IGF content.
16 . The topical composition of claim 15 , wherein the vitamin A comprises about 0.05% to about 0.15% by weight of the composition.
17 . The topical composition of claim 16 , wherein the vitamin A comprises about 0.1% by weight of the composition.
18 . The topical composition of claim 14 , wherein the vitamin A is retinol.
19 . The topical composition of claim 15 , wherein the eggshell membrane or at least one component of eggshell membrane comprises about 0.35% by weight of the composition.
20 . The topical composition of claim 15 , wherein colostrum or extracts of colostrum rich in IGF content comprises about 0.35% by weight of the composition.
21 . The topical composition of claim 15 , wherein the dermatologically acceptable carrier comprises one or more agents selected from the group consisting of: sodium hyaluronate, phosphatidylcholine, isopropyl palmitate, cetearyl alcohol, glycerol monostearate, and dimethyl ethanolamine.
22 . The topical composition of claim 15 , wherein the pH of the composition is in the range from about 2.5 to about 6.0.
23 . The topical composition of composition of claim 22 , wherein the pH of the composition is in the range from about 3.0 to about 5.5.
24 . The topical composition of claim 23 , wherein the pH of the composition is in the range from about 3.8 to about 5.0.
25 . The topical composition of claim 15 , wherein the composition is a cream.
26 . A topical composition comprising:
about 0.1% by weight retinol;
about 0.35% to 0.7% by weight of at least one of peptide extract of colostrum which is rich in insulin like growth factor and optionally eggshell membrane; and
a dermatologically acceptable carrier comprising phosphatidylcholine.
27 . The topical composition of claim 26 , comprising 0.35% by weight IGF rich peptide extract of colostrum and 0.35% by weight eggshell membrane.
28 . A method for preparing a topical composition having a water phase, an oil phase, an aqueous DMAE mixture, vitamin A, one or more of eggshell membrane and colostrum or extracts thereof, and preservative agent, comprising the steps of:
adding the water phase to the oil phase;
mixing the water phase with the oil phase;
cooling to about 58° C.;
adding the preservative agent;
cooling to about 30° C.;
adding the vitamin A;
cooling to about 28° C.;
adding the one more component of eggshell membrane and colostrum;
homogenizing;
adding the DMAE mixture; and
overlaying the resulting mixture with nitrogen.
29 . A method for treatment of aging skin, comprising administering to the skin a composition comprising:
an effective amount of vitamin A;
an effective amount of at least one compound selected from the group consisting of: insulin like growth factors (“IGF”), colostrum, IGF extracted from colostrum, a peptide extract of colostrum which is rich IGF, and avian eggshell membrane; and
a dermatologically acceptable carrier.
30 . A method for stimulating epidermis and dermis layers of the skin, comprising administering to the skin the composition comprising:
an effective amount of vitamin A;
an effective amount of at least one compound selected from the group consisting of: insulin like growth factors (“IGF”), colostrum, IGF extracted from colostrum, a peptide extract of colostrum which is rich IGF, and avian eggshell membrane; and
a dermatologically acceptable carrier.